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Hydroxyfasudil (hydrochloride)

  Cat. No.:  DC9614   Featured
Chemical Structure
155558-32-0
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More than 5000 active chemicals with high quality for research!
Field of application
Hydroxyfasudil Hcl(HA1100 Hcl), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 155558-32-0
Chemical Name: Hydroxyfasudil HCl
Synonyms: 1(2H)-Isoquinolinone,5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1);HYDROXYFASUDIL MONOHYDROCHLORIDE;HA 1100 hydrochloride;HA-1100 (hydrochloride);1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate;HA1100;HA-1100 hydrochloride;HYDROXYFASUDIL;Hydroxyfasudil (HA-1100);Hydroxyfasudil (HA-1100) HCl;Hydroxyfasudil Hydrochloride;Hydroxyfasudil hydrochloride hydrate;5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone;1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride;Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate;Hydroxyfasudil (hydrochloride);HA1100 Hydrochloride;Hydroxyfasudil HCl;Hydroxy Fasudil Hydrochloride;1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl;Hydroxyfasudil(hydrochloride);C14H17N3O3S.ClH;BCP11069;IN1295;3725AH;F
SMILES: Cl[H].S(C1=C([H])C([H])=C([H])C2C(N([H])C([H])=C([H])C1=2)=O)(N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])(=O)=O
Formula: C14H18ClN3O3S
M.Wt: 343.826
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
In Vivo: Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure[2]. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats[3].
In Vitro: Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC50 of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC50 value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC8329 SLx-2119(KD-025,Belumosudil ) SLx-2119(KD-025) is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM; > 200 fold selecivity over ROCK1(IC50 =24 uM)
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DC7269 RKI-1447 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2.
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DC7774 Ripasudil(K-115) K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor; is in Phase II clinical development in patients with POAG or ocular hypertension.
DC9614 Hydroxyfasudil (hydrochloride) Hydroxyfasudil Hcl(HA1100 Hcl), metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.
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