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Home > Inhibitors & Agonists > Ras-Raf-MAPK-ERK > Ras

K-Ras-IN-1

  Cat. No.:  DC9906   Featured
Chemical Structure
84783-01-7
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More than 5000 active chemicals with high quality for research!
Field of application
K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 84783-01-7
Chemical Name: (2-Hydroxyphenyl)(Pyrrolidin-1-Yl)methanethione
Synonyms: K-Ras-IN-1;(2-Hydroxyphenyl)(Pyrrolidin-1-Yl)methanethione;(2-Hydroxy-phenyl)-pyrrolidin-1-yl-methanethione;o-hydroxythiobenzopyrrolidide;CBMicro_013683;MLS000974614;HMS2836K18;BCP19051;SMSF0013305;1-(2-Hydroxythiobenzoyl)pyrrolidine;STL436470;2-(1-pyrrolidinylcarbonothioyl)phenol;2-(1-Pyrrolidinylcarbothioyl)phenol #;CB05192;SMR000496877;1-[(2-Hydroxypheny
SMILES: S=C(C1=C([H])C([H])=C([H])C([H])=C1O[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
Formula: C11NOsH13
M.Wt: 207.292
Purity: >98%
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)
References: [1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. [2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC72237 BI-0474 BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
DC70234 AZD4625 AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.AZD4625 is a clinical development candidate for the treatment of KRASG12C positive tumors.
DC26136 MRTX849(Adagrasib) MRTX849(Adagrasib) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. MRTX849 covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bou
DC7344 ZCL 278 ZCL278 is a Cdc42 small molecule modulator that directly binds to Cdc42 (Kd=11.4 uM) and inhibits Cdc42-intersectin interaction.
DC8725 NSC 23766 NSC 23766 is a specific inhibitor of the binding and activation of Rac GTPase.
DC7467 ML-098 ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).
DC9906 K-Ras-IN-1 K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
DC8816 ARS-853 ARS-853 is a selective, covalent inhibitor of KRAS-G12C that inhibits mutant KRAS driven signaling by binding to the GDP bound oncoprotein and preventing activation.
DC12031 ARS-1630 ARS-1630 is the R-conformational atropisomer of ARS-1620, 1,000-fold less potent than ARS-1620 (1.2 ± 0.6 M-1s-1) and thus acts as a unique inactive control compound..
DC10725 ARS-1620 ARS-1620 is a covalent compound with high potency and selectivity for KRAS-G12C.
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