Pirtobrutinib (LOXO-305)

  Cat. No.:  DC50020   Featured
Pirtobrutinib (LOXO-305)
Chemical Structure
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Field of application
LOXO-305 is an investigational, novel, selective non-covalent Bruton’s tyrosine kinase (BTK) inhibitor. LOXO-305 was designed to reversibly bind BTK, preserve activity in the presence of the acquired resistance, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors.LOXO-305 is a highly selective, non-covalent BTKi that inhibits both wild type (WT) and C481-mutated BTK with equal low nM potency was developed.
Cas No.: 2101700-15-4
Chemical Name: 1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]
Synonyms: LOXO-305; RXC-005;LOXO 305;LOXO305;RXC 005;RXC005
SMILES: FC([C@]([H])(C([H])([H])[H])N1C(=C(C(N([H])[H])=O)C(C2C([H])=C([H])C(C([H])([H])N([H])C(C3C([H])=C(C([H])=C([H])C=3OC([H])([H])[H])F)=O)=C([H])C=2[H])=N1)N([H])[H])(F)F
Formula: C22H21F4N5O3
M.Wt: 479.42
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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