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PF-06885249(PF249)

  Cat. No.:  DC80099   Featured
Chemical Structure
1467059-70-6
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More than 5000 active chemicals with high quality for research!
Field of application
PF-249(PF06885249) is a potent, selective AMPK β1-containing complexes activator; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 296 nM, potently inhibits de novo lipogenesis (IC50=15 nM) in primary rat hepatocytes.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1467059-70-6
Chemical Name: 6-chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid
Synonyms: PF06885249;PF 06885249
SMILES: N1C2=C(C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)C(C(O)=O)=C1
Formula: C17H16ClN3O3
M.Wt: 345.783
Purity: >98%
Publication: Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159. View Related Products by Target AMPK
Description: PF-249 is a potent, selective AMPK β1-containing complexes activator; increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 296 nM, potently inhibits de novo lipogenesis (IC50=15 nM) in primary rat hepatocytes.
References: Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159. View Related Products by Target AMPK
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