PF00835231

  Cat. No.:  DC50035   Featured
PF00835231
Chemical Structure
870153-29-0
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More than 5000 active chemicals with high quality for research!
Field of application
PF00835231(SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 µM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 µM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
Cas No.: 870153-29-0
Chemical Name: N-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide
Synonyms: Compound 5h (SARS-CoV-2 inhibitor) ;PF00835231;PF-00835231;PF 00835231
SMILES: COc1c2c([nH]c(c2)C(N[C@H](C(N[C@H](C(c2sc3c(cccc3)n2)=O)C[C@H]2C(=O)NCC2)=O)CC(C)C)=O)ccc1
Formula: C30H33N5O5S
M.Wt: 575.68
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication--Nature Communications volume 12, Article number: 668 (2021)
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MSDS
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MSDS_27571_DC50035
COA
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Cat. No. Product name Field of application
DC50035 PF00835231 PF00835231(SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 µM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 µM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
DC50030 GRL-1720 GRL-1720 is an irreversible, covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 15 µM.
DC39025 FOY-251 FOY 251 is a metabolite of Camostat and a pollen protease inhibitor for prevention and control of allergy.
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DC28041 BIOTIN-PEG4-SBP1(spike-binding peptide 1) Biotin modification of SBP1.SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein. SBP1 specifically binds SARS-CoV-2-RBD with low nanomolar affinity. SBP1 to the RBD was determined to be 47 nM with the average Kon = 4.69*104M-1S-1 and Koff=2.2*10-3.The interaction between SBP1 and the RBD of SARS-CoV-2 spike protein was validated by bio-layer interferometry. The KD, derived from protein association and dissociation kinetics, was found to be 47 nM after averaging the fitting values at different protein concentrations. The amino acid sequence of SBP1 is entirely derived from human ACE2 and should be recognized as endogenous by the human immune system. This feature could be highly beneficial in later stages of pre-clinical development.
DC28040 SBP1(spike-binding peptide 1) SBP1(spike-binding peptide 1) is a first-in-class peptide binder to the SARS-CoV-2 spike protein. SBP1 specifically binds SARS-CoV-2-RBD with low nanomolar affinity. SBP1 to the RBD was determined to be 47 nM with the average Kon = 4.69*104M-1S-1 and Koff
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