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PF00835231

  Cat. No.:  DC50035   Featured
Chemical Structure
870153-29-0
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More than 5000 active chemicals with high quality for research!
Field of application
PF00835231(SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 µM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 µM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 870153-29-0
Chemical Name: PF00835231
Synonyms: Compound 5h (SARS-CoV-2 inhibitor) ;PF00835231;PF-00835231;PF 00835231
SMILES: COc1c2c([nH]c(c2)C(N[C@H](C(N[C@H](C(c2sc3c(cccc3)n2)=O)C[C@H]2C(=O)NCC2)=O)CC(C)C)=O)ccc1
Formula: C30H33N5O5S
M.Wt: 575.68
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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DC50035 PF00835231 PF00835231(SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 µM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 µM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
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