TNO155|TNO-155|SHP2 inhibitor|DC Chemicals|CAS 1801765-04-7

Cas No.:	1801765-04-7
Chemical Name:	TNO155
Synonyms:	TNO155 ，TNO-155 ，TNO 155
SMILES:	N[C@H]1C2(CCN(C3C=NC(SC4C=CN=C(N)C=4Cl)=C(N)N=3)CC2)CO[C@H]1C
Formula:	C₁₈H₂₄ClN₇Os
M.Wt:	421.95
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. TNO155: SHP2 inhibitor

Description:	TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].
In Vivo:	The oral bioavailability in mouse, rat and money are 78%, 86%, and 60%, respectively[1].
In Vitro:	TNO155 shows an IC50 of 0.008 µM in KYSE520 pERK assay and shows an IC50 of 0.100 µM in KYSE520 5-day cell proliferation assay. The off-target IC50 values are 18 µM, 6.9 µM, and 11 µM for Cav1.2, VMAT, and SST3, respectively[1].

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