Cat. No.:  DC57111   Featured
Chemical Structure
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays.
Cas No.: 2561494-77-5
Chemical Name: 2H -1,4-Benzoxazine-7-carboxamide, N -cyclopropyl-3,4-dihydro-3-oxo-N -[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- (ACI)
Synonyms: UNC6934;UNC-6934;UNC 6934
Formula: C24H21N5O4
M.Wt: 443.16
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication: Nature Chemical Biology, A chemical probe targeting the PWWP domain alters NSD2 nucleolar localizationMatthieu Schapira、Dalia Barsyte-Lovejoy、David Dilworth,Lindsey I. James
In Vivo:
In Vitro:
Kinase Assay:
Cell Assay:
Animal Administration:
Cat. No. Product name Field of application
DC60200 SEP-363856 SEP-363856 isomer
DC60199 Bifluranol Bifluranol (brand name Prostarex; former developmental code name BX-341) is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol that has been used as an antiandrogen in the United Kingdom in the treatment of benign prostatic hyperplasia. It exerts functional antiandrogen effects by binding to and activating the estrogen receptor in the pituitary gland, consequently suppressing the secretion of luteinizing hormone (and hence acting as an antigonadotropin) and thereby reducing gonadal androgen production and systemic androgen levels.
DC60198 GN44028 GN44028 inhibits HIF-1α. GN44028 surpresses HIF-1α transcriptional activity without affecting both HIF-1α protein accumulation and HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions, suggesting that GN44028 probably affectes the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer.
DC60197 Pinacol
DC60196 K-Ras G12C-IN-4
DC60195 Batefenterol Succinate Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.
DC60194 ARQ-087·2HCl
DC60193 Sitagliptin phosphate
DC60191 Tenofovir Alafenamide Impurity 1
DC60190 TAS4464 TAS4464 is a highly potent and selective inhibitor of NEDD8 (IC50 of 0.955 nM). TAS4464 selectively inhibited NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibited cullin neddylation and subsequently induced the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IκBα in human cancer cell lines. TAS4464 showed greater inhibitory effects than those of the known NAE inhibitor MLN4924 both in enzyme assay and in cells.