UNC6934|UNC-6934|DC Chemicals

Cas No.:	2561494-77-5
Chemical Name:	2H -1,4-Benzoxazine-7-carboxamide, N -cyclopropyl-3,4-dihydro-3-oxo-N -[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]- (ACI)
Synonyms:	UNC6934;UNC-6934;UNC 6934
SMILES:	O=C(NC=1N=CN=CC1)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
Formula:	C₂₄H₂₁N₅O₄
M.Wt:	443.16
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Publication:	Nature Chemical Biology, A chemical probe targeting the PWWP domain alters NSD2 nucleolar localizationMatthieu Schapira、Dalia Barsyte-Lovejoy、David Dilworth,Lindsey I. James

Description:

UNC6934 is a potent and selective drug-like chemical probe to interrogate the function of NSD2-PWWP1 with Kd of 91 nM.UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 ± 0.23 microM. UNC7145, a closely-related control compound, with an iso-propyl group replacing a cyclo-propyl group, is inactive by SPR and NanoBret assays.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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