BI-2865 |CAS 2937327-93-8|DC Chemicals

Cas No.:	2937327-93-8
Chemical Name:	BI-2865
Synonyms:	BI-2865
SMILES:	C12CCC[C@](C)(C3ON=C(C4=NC=CC(O[C@H]([C@@H]5CCCN5C)C)=N4)N=3)C=1C(C#N)=C(N)S2
Formula:	C₂₃H₂₇N₇O₂S
M.Wt:	465.571182489395
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023 May 31

Description:

BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 blocked nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants, including G12A/C/D/F/V/S, G13C/D, V14I, L19F, Q22K, D33E, Q61H, K117N and A146V/T. Inhibition of downstream signalling and proliferation was restricted to cancer cells harbouring mutant KRAS, and drug treatment suppressed KRAS mutant tumour growth in mice, without having a detrimental effect on animal weight.

References:

[1]. Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023 May 31

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