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SG-094

  Cat. No.:  DC72651   Featured
Chemical Structure
2922283-37-0
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More than 5000 active chemicals with high quality for research!
Field of application
SG094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2922283-37-0
Chemical Name: SG-094
SMILES: COC1=C(OC2=CC=CC=C2)C=C(C(CC3=CC=C(OC4=CC=CC=C4)C=C3)N(C)CC5)C5=C1
Formula: C30H29NO3
M.Wt: 451.56
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Müller M, et, al. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27.
Description: SG094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer.
Target: TPC2[1]
In Vitro: SG-094 (72 hours) shows antiproliferative effects against RIL175 cells, with an IC50 of 3.7 μM[1]. SG-094 (10 μM) blocks PI(3,5)P2-elicited TPC2 currents on isolated endolysosomes from HEK293 cells expressing TPC2-EGFP[1]. SG-094 (10 μM; pretreated for 1 h) significantly reduces VEGF-induced phosphorylation of eNOS, JNK, MAPK, and AKT without decreasing their total protein levels in HUVECs[1]. SG-094 (1-5 μM; pretreated for 1 h) increases OCR/ECAR ratios of RIL175 WT cells after glucose starvation[1].
References: [1]. Müller M, et, al. Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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