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VK-II-86

  Cat. No.:  DC70883   Featured
Chemical Structure
955371-84-3
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More than 5000 active chemicals with high quality for research!
Field of application
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 955371-84-3
Chemical Name: VK-II-86
Synonyms: VK-II-86;4-(9H-carbazol-4-yloxy)-1-[2-(2-methoxyphenoxy)ethylamino]butan-2-ol;2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-;methoxyphenoxy)ethylamino);methoxyphenoxy)ethylamino);GTPL10161;GTPL10161;GTPL10161;GLXC-03770;GLXC-03770;GLXC-03770;AKOS037643460;AKOS037643460;AKOS037643460;4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol;4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol;4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol;compound 8 [PMID: 24124794];compound 8 [PMID: 24124794];compound 8 [PMID: 24124794];AS-16495;AS-16495;AS-16495;4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol;4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol;4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol;CS-0033973;CS-0033973;CS-0033973;4-(9H-carbazol-4-yloxy)-1-(2-(2- methoxyphenoxy)ethylamino) butan-2-ol;4-(9H-carbazol-4-yloxy)-1-(2-(2- methoxyphenoxy)ethylamino) butan-2-ol;4-(9H-carbazol-4-yloxy)-1-(2-(2-;4-(9H-carbazol-4-yloxy)-1-(2-(2- methoxyphenoxy)ethylamino) butan-2-ol;4-(9H-carbazol-4-yloxy)-1-(2-(2-;NCGC00388561-04;4-(9H-carbazol-4-yloxy)-1-(2-(2-;NCGC00388561-04;EX-A4685;NCGC00388561-04;EX-A4685;DA-68614;EX-A4685;DA-68614;BDBM50411862;DA-68614;BDBM50411862;955371-84-3;BDBM50411862;955371-84-3;4-(9H-CARBAZOL-4-YLOXY)-1-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}BUTAN-2-OL;955371-84-3;4-(9H-CARBAZOL-4-YLOXY)-1-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}BUTAN-2-OL;HY-111013;4-(9H-CARBAZOL-4-YLOXY)-1-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}BUTAN-2-OL;HY-111013;SCHEMBL14388550;HY-111013;SCHEMBL14388550;CHEMBL2440787;SCHEMBL14388550;CHEMBL2440787;CHEMBL2440787
SMILES: C(NCCOC1=CC=CC=C1OC)C(O)CCOC1C2C3=C(NC=2C=CC=1)C=CC=C3
Formula: C25H28N2O4
M.Wt: 420.500826835632
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC72651 SG-094 SG094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer.
DC70883 VK-II-86 VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
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DC44831 MCU-i4 MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.,MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft.[1]
DC42326 Azumolene Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research.
DC41018 SR33805 SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts.
DC28967 Gallopamil hydrochloride Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent.
DC10947 FPL64176 FPL64176 is a potent L-type Ca++ channel activator with EC50 of 16 nM.
DC10948 CDN1163 CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes; increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells; improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice; CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers.
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