Phospholine is an antibiotic. The IC50 (μg/mL) of Ll 210, P388 and EL-4 cells are 3.37, 2.20 and 1.99, respectively.

PAA-38 is a highly potent selective inhibitor targeting bacterial prolyl-tRNA synthetase (ProRS). PAA-38 againsts Pseudomonas aeruginosa ProRS (PaProRS) with a Kd value of 0.399 nM and an IC50 value of 4.97 nM. PAA-38 againsts human cytoplasmic ProRSs (HsProRS) with an IC50 value of 35.5 nM. PAA-38 demonstrates an in vitro antibacterial activity of minimum inhibitory concentration (MIC) = 4-8 μg/mL.

Nothramicin is an anthracycline antibiotic with anti-mycobacterial activity .

NFC nitro probe 1 (compound 18) is an NFC termed probe for Mtb detection. NFC nitro probe 1 (compound 18) shows high potency for R-Mtb and NR-Mtb.

N14G-Fe, the Fe3+-chelated form of N14G, identifies Mtb in sputum samples with tuberculosis, exhibiting exceptional fluorescence. N14G-Fe can effectively traverse the cell wall and inner membrane region where IrtAB is located.

Myramistin (Miramistin) is an antibacterial agent targeting bacterial cell membrane. Myramistin can bind to the negatively charged surface of bacteria through its cationic properties, disrupt the integrity of the bacterial cell membrane, inhibit bacterial metabolism and growth, and induce cell death, thus exerting antibacterial activity.

Mutalomycin is a polyether antibiotic. Mutalomycin has anti-Gram-positive bacteria, anti-mycoplasma and anti-coccidial activity.

MRSA antibiotic 2 (compound 2) shows MIC of 2 μg/mL for S. aureus (MRSA). MRSA antibiotic 2 selectively target Gram-positive bacteria over Gram-negative bacteria and human cells.

MMV1578877 is a Mycobacterium ulcerans inhibitor (IC50: 0.37 μM). MMV1578877 can be used in the study of Buruli ulcer (BU).

MLEB-22043 is a synthetic siderophore-monobactam conjugate that is taken up into bacteria via its synthetic siderophore component by TonB-dependent transporters. Once inside the bacteria, it exerts antibacterial activity through its β-lactam component. MLEB-22043 is a broad-spectrum antibiotic with significant inhibitory activity against Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.

Minimycin (Oxazinomycin) is a nucleoside antibiotic with a broad-spectrum antibacterial activity. Minimycin has inhibitory effect on mouse Ehrlich ascites carcinoma, ascites type and solid type sarcoma-180.

Malioxamycin is an antibiotic that inhibits Gram-negative bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls and promoting the formation of spheroplasts.

Lycomarasmin has the inhibitory effect of lactobacillus casei, and it is a plant toxin.

Emericid (Lonomycin A) has anti-Gram-positive bacterial activity and can be used for the study of coccidiosis of poultry.

Keto lovastatin is an impurity of Lovastatin with antibacterial activity. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

K13787 is an acetohydroxyacid synthase (AHAS) inhibitor with antibacterial activity. K13787 has antibacterial activity against a variety of nontuberculous mycobacteria (NTM) and clarithromycin (CLR) resistant strains.

Julimycin B2 has anti-Gram-positive bacteria and anti-virus activity and it has effects on ehrman ascites carcinoma in mice.

JSF-4898 is an orally active inhibitor of the MenG enzyme in Mycobacterium tuberculosis. JSF-4898 has MIC of 0.78 μM against Mycobacterium tuberculosis H37Rv. JSF-4898 can enhance the efficacy of Rifampicin in a subacute model of Mycobacterium tuberculosis infection in mice.

JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research.

Javanicin is an antibacterial agent with certain antibacterial activity against pathogenic bacteria such as Bacillus megaterium, Staphylococcus aureus, Salmonella typhi, and Escherichia coli. Javanicin has weak cytotoxicity against the human lung cancer cell line.

Janthinocin B has strong activity of anti-Gram-positive bacteria and moderate anti-Gram-negative bacteria.

Janthinocin A has strong activity of anti-Gram-positive bacteria and moderate anti-Gram-negative bacteria.

JAK05 exhibits inhibitory activity against Helicobacter pylori, inhibits strains J63, J196 and J107 with MIC of 3-5 µg/mL. JAK05 exhibits binding affinity to H+/K+-ATPase, COX-1/2, TNF-α and PGE2, reveals antioxidant and anti-inflammatory activities. JAK05 exhibits anti-ulcer activity in rat ethanol-induced gastric ulcer models.

Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.

Isoleucylcysteine, a dipeptide composed of isoleucine and cysteine, is an intermediate peptide in bacitracin biosynthesis.

Isoegomaketone is a sesquiterpenoid that can be isolated from Perilla frutescens essential oil. Isoegomaketone exhibits anti-inflammatory, antioxidant, anti-cancer, anti-mycobacterial, anti-arthritic and anti-obesity effects.

IPMCL-28b is an antibacterial agent targeting the bacterial cell membrane. Its minimum inhibitory concentration (MIC) against Staphylococcus aureus ATCC 25923 is 1.56 μg/mL, and the MIC against methicillin-resistant Staphylococcus aureus (MRSA) is 6.25 μg/mL. IPMCL-28b is expected to be used in the research of the anti-infection field.

Ilicicolin B (LL-Z 1272β) inhibits Bacillus carbonifera with the concentration of 6 μg/mL and its toxic concentration to Hela cells is 0.3 μg/mL.

HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent.

His-ADPR is a Toll/interleukin-1 receptor (TIR) domain protein that produces an immune signaling molecule. His-ADPR is generated in response to phage infection and activates the cognate Thoeris effector by binding a Macro domain located at the C terminus of the effector protein.