E-4031

Cas No.:	113559-13-0
Chemical Name:	E4031 HCl
Synonyms:	Methanesulfonamide,N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-,hydrochloride (1:2);E-4031 (hydrochloride);E-4031 dihydrochloride;Methanesulfonamide,N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-,hy...;1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidine dihydrochloride;AC1MJ7N7;CHEMBL536480;E 4031 dihydrochloride;E-4031;Methanesulfonamide, N-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carbonyl)phenyl)-,dihydrochloride;N-(4-{1-[2-(6-methylpyridin-2-yl)ethyl]piperidin-4-yl}-carbo;N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride;E 4031;1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid;N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride;E4031;N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamidedihydrochloride;N-(4-(1-(2-(6-Me;E-4031 2HCl;113559-13-0;UNII-814AT2BQO7;CS-3721;HY-15551;N-[4-[1-[2-(6-methyl-2-pyridyl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide;dihydrochloride;bis(((Z)-4-Oxopent-2-en-2-yl)oxy)zinc;DTXSID30150461;SCHEMBL9444378;C21H27N3O3S.2HCl;N-(4-(1-(2-(6-Methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide 2HCl (e-4031);ZQBNWMFBOSOOLX-UHFFFAOYSA-N;E-4031, >=98% (HPLC), solid;METHANESULFONAMIDE, N-(4-((1-(2-(6-METHYL-2-PYRIDINYL)ETHYL)-4-PIPERIDINYL)CARBONYL)PHENYL)-, HYDROCHLORIDE (1:2);AS-53722;Methanesulfonamide, N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-, hydrochloride (1:2);SR-01000597979-1;BCP07766;SR-01000597979;E-4031 Free;N-(4-(1-(2-(6-Methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide dihydrochloride;1-[2-(6-Methyl-2-pyridyl)ethyl]-4-(4-methylsulfonylaminobenzoyl)piperidine dihydrochloride;EX-A4539;MFCD01754739;AKOS015966715;HB1080;814AT2BQO7;P16946;s6627;4'-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide;n-(4-(1-(2-(6-methylpyridin-2-yl)ethyl)piperidine-4-carbonyl)phenyl)methanesulfonamide 2hcl; e-4031;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidine dihydrochloride;N-(4-{1-[2-(6-METHYLPYRIDIN-2-YL)ETHYL]PIPERIDINE-4-CARBONYL}PHENYL)METHANESULFONAMIDE DIHYDROCHLORIDE;DA-63087;N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phe...
SMILES:	Cl[H].Cl[H].S(C([H])([H])[H])(N([H])C1C([H])=C([H])C(=C([H])C=1[H])C(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(C([H])([H])[H])=N2)C([H])([H])C1([H])[H])=O)(=O)=O
Formula:	C21H29Cl2N3O3S
M.Wt:	474.44
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel. in vitro: Dofetilide and E-4031 induced EADs or TdP in all assays (50-83%), and the induction correlated with a significant increase in beat-to-beat variability of repolarization. E-4031 (0.1 mumol/L) significantly prolonged cycle length and action potential duration, depolarized maximum diastolic potential, and reduced both the upstroke velocity of the action potential and the diastolic depolarization rate. in vivo: E-4031 in doses of 0.01 and 0.1 mg/kg that can provide the plasma concentrations effectively to inhibit IKrin vitro significantly delayed the repolarization beyond the initiation of diastole, resulting in the inversion of electro-mechanical coupling, which provides an ideal proarrhythmic substrate, while the durations of left ventricular systole and diastole remained the same. Bepridil and E-4031 prolonged QT interval and ARI in all LV layers, though the magnitude of prolongation was greatest in Mid, increasing the transmural ARI dispersion, particularly during bradycardia.