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Cardiovascular Disease

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Cat. No. Product Name Field of Application Chemical Structure
DC4210 Azilsartan kamedoxomil Featured
Azilsartan medoxomil is an angiotensin II receptor antagonist indicated for the treatment of mild to moderate essential hypertension.
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DC9380 Cleviprex Featured
Clevidipine(Clevidipine) is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.
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DC9160 Cilnidipine Featured
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
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DC7125 Evacetrapib (LY2484595) Featured
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
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DCAPI1469 azilsartan Featured
Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM.
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DC9185 Candesartan cilexetil Featured
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
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DC9623 Flecainide (acetate) Featured
Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
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DC2072 LXR623 Featured
LXR-623 is a novel Liver X Receptor modulator
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DC10947 FPL64176 Featured
FPL64176 is a potent L-type Ca++ channel activator with EC50 of 16 nM.
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DCAPI1442 Atorvastatin Calcium Featured
Atorvastatin Calcium
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DC9178 Ketanserin Tartrate
DC9113 Ketanserin
DC9461 Zatebradine
Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.
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DC7753 Zatebradine hydrochloride
Zatebradine hydrochloride is a bradycardic agent that creates use-dependent inhibition of hyperpolarization-activated current (If) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres.
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DCAPI1452 Valsartan
Valsartan is a nonpeptide angiotensin II AT1-receptor antagonist with an IC50 ranging from 39.5 to 116 μM. This in turn causes blood vessel dilation.
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DC11138 Guanabenz acetate
R15A inhibitor.
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DC6903 Lapaquistat Acetate (TAK-475)
Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.
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DC9443 Otamixaban
Otamixaban(FXV673) is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa.
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DC10324 Omapatrilat
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
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DC9179 Olmesartan MedoxoMil
Olmesartan medoxomil(Olmetec; Benicar; CS 866) is an angiotensin II receptor antagonist which is used as an anti-hypertensive.
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DCAPI1464 Olmesartan
Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction.
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DC9108 Nisoldipine
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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DC9170 Nicardipine hydrochloride
Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage.
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DC9456 MK-0354
MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b.
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DC9191 Metoprolol tartrate
Metoprolol is a cardioselective β1-adrenergic blocking agent.
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DC11315 Manidipine(CV-4093)
Manidipine is a dihydropyridine L- and T-type calcium channel blocker.
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DCAPI1419 Losartan
Losartan is a potent, non peptide antagonist of the angiotensin II receptor type 1. This receptor initiates a signal cascade that causes vasoconstriction. Antagonism of this receptor in turn causes vasodilation by blocking the signal from angiotensin II.
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DC9123 Lisinopril Dihydrate
Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
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DC10233 Guanfacine Hydrochloride
Guanfacine Hydrochloride is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
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DCAPI1596 Metroprolol succinate
For the detailed information of Metroprolol succinate, the solubility of Metroprolol succinate in water, the solubility of Metroprolol succinate in DMSO, the solubility of Metroprolol succinate in PBS buffer, the animal experiment (test) of Metroprolol succinate, the cell expriment (test) of Metroprolol succinate, the in vivo, in vitro and clinical trial test of Metroprolol succinate, the EC50, IC50,and Affinity of Metroprolol succinate, Please contact DC Chemicals..
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