Cat. No. | Product Name | Field of Application | Chemical Structure |
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DC7797 | ML365 Featured |
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).
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DC10091 | ML364 Featured |
ML364 is an USP2 inhibitor.xtracted from patent WO 2016134026 A1, compound example 10G.
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DC9994 | ML-346 Featured |
ML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
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DC10743 | ml335 Featured |
ML335 is a selective activator of both TREK-1 and TREK-2.
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DC10121 | ML-329 Featured |
ML329 is a small molecule inhibitor of the MITF molecular pathway.
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DC10711 | ML-327 Featured |
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
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DC7740 | ML-324 Featured |
ML-324 is a JMJD2 histone demethylase inhibitor (JMJD2 IC50 = 920 nM)
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DC7468 | ML-323 Featured |
ML323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively.
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DC7798 | ML-277 Featured |
ML-277 is a potent activator of KCNQ1 ( K(v)7.1) channels (EC50 = 260 nM).
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DC9682 | ML-264 Featured |
ML264 is a novel small molecule inhibitor of Krüppel-like factor 5 (KLF5).
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DC10790 | ML-239 Featured |
ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 µM) over an isogenic control cell line (EC50 = 27.6 µM).
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DC7781 | ML-224 Featured |
ML-224 (ANTAG3) is a selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice.
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DC10793 | ML221 Featured |
ML221 is an antagonist of the apelin (APJ) receptor.
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DC10466 | ML-18 Featured |
ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM). ML-18 inhibits lung cancer growth.
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DC7901 | ML-141 Featured |
ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.
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DC7467 | ML-098 Featured |
ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).
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DC9874 | ML-348(ML348) Featured |
ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
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DC10544 | MKC3946 Featured |
MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research.
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DC9901 | Verubecestat (MK-8931) Featured |
MK-8931 is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
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DC12020 | MK-8722 Featured |
MK-8722 is a systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.
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DC5034 | MK8245 Featured |
MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
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DC7745 | Filorexant(mk-6096) Featured |
MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R currently in clinical development for insomnia.
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DC4179 | Niraparib(MK4827) free base Featured |
MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
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DC7465 | MK-2206 2HCl Featured |
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
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DC1070 | MK-1775(AZD-1775,Adavosertib) Featured |
MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM.
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DC9966 | MK-1064 Featured |
MK-1064 is a selective orexin 2 receptor antagonist (2-SORA) for the research of insomnia.
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DC8041 | MK-0941 Featured |
MK-0941 is a novel Glucokinase activator (GKA)
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DC10045 | MK-0557 Featured |
MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss.
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DC9836 | Mivebresib(ABBV-075) Featured |
Mivebresib is a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo.
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DC8935 | Mitomycin C Featured |
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.
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