Cyclosporin A-d3 is a deuterium-enriched isotopologue of Cyclosporin A (HY-B0579), designed for metabolic stability studies and quantitative mass spectrometry applications.

HGC652 is a first-in-class molecular glue that selectively recruits the E3 ubiquitin ligase TRIM21 to form a ternary complex with NUP98, triggering targeted degradation of NUP155 and nuclear pore complex (NPC) proteins. This unique mechanism induces potent cytotoxicity across multiple cancer types, with activity correlating with cellular TRIM21 expression levels.

PROTAC GSPT1 degrader-2 (compound A) is a highly efficient molecular glue that achieves near-complete GSPT1 degradation (>95%). This compound demonstrates potent anti-proliferative activity in HL-60 leukemia cells, with an IC50 value of 10 nM, highlighting its therapeutic potential.

WIZ degrader 8 (compound 10) is a potent and selective molecular glue that induces targeted degradation of the transcription factor WIZ, resulting in robust upregulation of fetal hemoglobin (HbF) expression. This dual activity—WIZ depletion coupled with HbF induction—positions it as a promising therapeutic candidate for sickle cell disease.

Pan-RAS-IN-5 (compound 7A) is a molecular glue that induces a functional ternary complex between cyclophilin A (CYPA) and activated RAS (RAS-ON), effectively disrupting RAF recruitment and downstream signaling. This unique mechanism translates to potent anti-tumor activity.

Novel positive allosteric modulator (PAM) of the GLP-1R, enhancing insulin secretion in a glucose-, ligand- and GLP-1R-dependent manner

GSPT1 degrader-6 (compound 8) is a highly potent molecular glue that induces targeted degradation of GSPT1, demonstrating exceptional activity with a DC50 of 13 nM.

GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue designed to reinforce the glucocorticoid receptor (GR)-14-3-3 protein interaction. By selectively stabilizing this complex, it effectively disrupts GR signaling and serves as a versatile scaffold for developing targeted molecular glues.

XYD049 (compound 7d) is a CRBN-recruiting molecular glue that selectively degrades GSPT1 with high potency (DC50 = 19 nM), demonstrating therapeutic potential against MYC-driven castration-resistant prostate cancer (CRPC).

UNC8732 (TFA salt) is a bifunctional agent that simultaneously inhibits NSD2 methyltransferase activity and promotes its targeted degradation, offering dual epigenetic modulation.

BRD9 Degrader-3 (compound B20) is a highly potent molecular glue that induces targeted BRD9 degradation, demonstrating exceptional activity with a DC50 below 1.25 nM.

CDK4 degrader 1 (ML 1–71) is a molecular glue compound that selectively induces cyclin-dependent kinase 4 (CDK4) degradation through targeted ubiquitin-proteasome system recruitment.

UNC8732 is a dual-functional compound that both inhibits and degrades NSD2, offering a two-pronged approach to targeting this epigenetic regulator.

IKZF1-degrader-2 (Compound 3) is a targeted molecular glue that induces selective degradation of IKZF1, demonstrating potent anticancer efficacy with an advantageous safety profile.

Z-NCTS is a sequence-selective RNA-binding molecule that specifically targets 5’-r(XGG)-3’/5’-r(XGG)-3’ mismatches (where X = U or A), functioning as a molecular glue to stabilize these RNA duplex structures.

CQ627 is a targeted molecular glue that promotes RIOK2 degradation through the ubiquitin-proteasome pathway by bridging interactions between RIOK2 and the E3 ligase RNF126, achieving a DC50 of 410 nM in MOLT4 leukemia cells. This compound demonstrates multi-modal anticancer activity, including: (1) dose-dependent apoptosis induction, (2) G2/M phase cell cycle arrest, and (3) broad-spectrum antiproliferative effects across cancer cell lines. Furthermore, CQ627 shows significant in vivo efficacy in MOLT4 xenograft models, validating its therapeutic potential.

STING Degrader-1 (compound 2) is a covalent molecular glue that simultaneously engages STING and its cognate E3 ligase, inducing targeted protein degradation. The compound exhibits a characteristic hook effect, achieving maximal STING depletion (75%) at 10 μM, while higher concentrations (30 μM) show reduced degradation efficiency (~30%).

GSPT1 degrader-2 (Compound 210) is an orally bioavailable molecular glue that achieves potent, sub-30 nM degradation of GSPT1 (DC50 < 30 nM), demonstrating robust antitumor efficacy in preclinical models.

GSPT1 degrader-1 (compound 9q) is a potent molecular glue that mediates targeted degradation of G1-to-S phase transition protein 1 (GSPT1) through the ubiquitin-proteasome pathway. This compound exhibits dual biological activity by inducing cell cycle arrest at the G0/G1 phase checkpoint and triggering apoptotic signaling cascades.

IKZF3 degrader 1 (compound 19a) is a potent molecular glue that induces targeted IKZF3 degradation (EC50 = 12 nM) by facilitating its recruitment to the cereblon (CRBN) E3 ubiquitin ligase complex. This enforced protein-protein interaction triggers subsequent ubiquitination and proteasomal elimination of IKZF3.

AR Degrader-1 (Compound ML 2-9) is a monovalent molecular glue that selectively targets the androgen receptor (AR) for degradation via recruitment of the DCAF16 E3 ubiquitin ligase. Demonstrating a favorable safety profile, this compound effectively degrades AR in LNCaP prostate cancer cells without inducing significant cytotoxicity.

BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue that orchestrates targeted BRD4 degradation through ternary complex formation with the E3 ligase RNF126. This compound selectively engages both BRD4 isoforms (long and short) for proteasomal elimination, demonstrating pan-isoform degradation capability in cellular systems.

3-Indoleacetic acid (Standard) serves as an analytically validated reference material for the phytohormone indole-3-acetic acid (IAA). Designed for precision research applications, this auxin-class plant growth regulator modulates fundamental developmental processes including cellular expansion, tissue differentiation, and organ morphogenesis, driving vegetative growth in plant systems.

ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular glue that stabilizes the ChREBP/14-3-3 protein complex with an EC50 of 3.8 μM. By enhancing this interaction, the compound demonstrates cytoprotective effects against glucolipotoxicity in pancreatic β cells while preserving cellular function. These properties position it as a promising investigational tool for type 2 diabetes research.

BRD9 Degrader-2 (Compound B11) is a highly potent and efficient molecular degrader of BRD9, achieving sub-nanomolar degradation activity (DC50 ≤1.25 nM) with maximal degradation exceeding 75%. This compound represents a promising chemical tool for investigating BRD9-dependent oncogenic pathways in cancer research.

AR Degrader-2 (Compound 2) is a molecular glue compound that induces targeted degradation of the androgen receptor (AR), demonstrating potent activity with a DC50 ranging from 0.3 to 0.5 μM in VCaP prostate cancer cells.

rac-Lenalidomide-13C5 is a carbon-13 labeled racemic variant of lenalidomide, designed for tracer studies in pharmacokinetic and metabolic research.

Lenalidomide-13C5,15N is an isotopically labeled analog of lenalidomide (HY-A0003; CC-5013), a thalidomide-derived molecular glue compound. This orally bioavailable immunomodulator functions through selective cereblon (CRBN) E3 ubiquitin ligase engagement, mediating targeted ubiquitination and proteasomal degradation of lymphoid transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 complex. The compound demonstrates dual therapeutic activity by both suppressing proliferation of mature B-cell malignancies (including multiple myeloma) and enhancing T-cell immunostimulation through IL-2 induction.

3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4) is a deuterium-stabilized isotopologue of the endogenous auxin phytohormone 3-indoleacetic acid (HY-18569). As the predominant natural auxin, 3-IAA regulates fundamental plant growth processes, including cellular elongation and proliferation, when supplemented in plant tissue culture systems.

Antitumor agent-100 (compound A6) hydrochloride is an orally bioavailable molecular glue that selectively targets the PDE3A-SLFN12 complex (IC50 = 0.3 μM). By binding to the PDE3A catalytic pocket, it stabilizes SLFN12 interaction, subsequently inhibiting protein translation and triggering apoptotic cell death. This dual mechanism underlies its potent antitumor activity.