Novel potent inhibitor of

Partial agonist at GABAA benzodiazepine receptors with sedative and anxiolytic effects

Novel antiviral agent, potently against Rabies virus (RABV) targeting host-rabies virus protein-protein interactions

Natural ent-kaurane diterpenoid, markedly stimulates the expression of NKG2D ligands on hepatocellular carcinoma (HCC) cells, considerably enhancing their recognition and lysis by NK cells, covalently inhibiting peroxiredoxins I/II (Prxs-I/II) catalytic a

Fluorescent PARP1 Inhibitor for Glioblastoma Imaging

Novel Selective Cell-Active Inhibitor of PARP10

Novel highly selective dual PARP1/BRD4 inhibitor (PARP1 IC 50 =49nM; BRD4 IC 50 =202nM), repressing the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells in vitro and in vivo

Potent and Novel Dual PARP/BRD4 Inhibitor for Efficient Treatment of Pancreatic Cancer

Novel potent phosphodiesterase 3 inhibitor, suppressing the asthmatic response and showing both bronchodilating and anti-inflammatory effects

Novel potent phosphodiesterase 3 inhibitor, suppressing the asthmatic response and showing both bronchodilating and anti-inflammatory effects

Non-selective contact herbicide, killing green plant tissue on contact, being highly toxic and linked to Parkinson's disease, generating reactive oxygen species (ROS), which causes cell death and potentially leading to acute respiratory distress syndrome

Acetylcholinesterase inhibitor, the active metabolite of the insecticide parathion

Selective cell-permeable inhibitor of non-muscle myosin II ATPases, being more stable and less phototoxic than Blebbistatin

Isomer of CID-5951923

Blebbistatin derivative, increasing water solubility, decreases the inherent fluorescence, stabilizing the molecule to circumvent its degradation by prolonged blue light exposure, and decreasing its phototoxicity while retaining the in vitro and in vivo a

Pathway Preferential Estrogen, activating the extranuclear signaling pathway without activity on the nuclear signaling pathway

Potent and highly selective small molecule inhibitor of thioredoxin reductase (TrxR)

Novel potent pan-Raf and receptor tyrosine kinase inhibitor, potently inhibits all subtypes of Rafs with IC50 values of 3.49 (BRafV600E), 8.86 (ARaf), 5.78 (BRafWT), and 1.65 nM (CRaf), respectively

Tamoxifen analogue; antiestrogenic

Biological Active Reagents

Inhibitor of the Cell_cycle>cell cycle from G0/G1 to S phase with powerful antiparasite activity

Novel TLR2 agonist as potential adjuvant for cancer vaccines

Potent serotonin-3 (5-HT3) receptor antagonist

Novel Ras-Signaling Modulator, targeting acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells

Potent dual dopamine-serotonin (DA/5-HT) releaser

Full DAT/5-HT transporter substrate; Non-neurotoxic releasing agent of serotonin, norepinephrine, and dopamine; Full agonist at 5-HT2B and partial agonist at 5-HT2C

Novel selective LYPLAL1 activator, increasing LYPLAL1’s catalytic activity likely by enhancing the efficiency of the catalytic triad charge-relay system, confering beneficial effects in a mouse model of diet-induced obesity

Full DAT/5-HT transporter substrate

Partial DAT/5-HT transporter substrate

Novel potent and selective inhibitor of protein arginine deiminase 3 (PAD3), having 15600 kinact/KI values and ≥10-fold selectivity for PAD3 over PADs 1, 2, and 4.