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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC8892 CP724714
CP-724714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc in cell-free assays. Phase 2.
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DC8251 CP-724,714
CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc. Phase 2.
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DC23415 CP-481715
CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity and .
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DC8543 CP465022 HCl
CP 465022 hydrochloride is a selective GluR (AMPA) antagonist which is non-competitive.
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DC21413 Cowanin
Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM.
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DC20933 Cotylimide-VI
Cotylimide-VI (CTL-VI) is a small molecule that perturbs plant hormone strigolactone accumulation and inhibits hypocotyl growth..
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DC9555 Cot inhibitor-2
Cot inhibitor-2 is a COT/Tpl2 inhibitor.
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DC9554 Cot inhibitor-1
Cot inhibitor-1 is a COT/Tpl2 inhibitor.
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DC8694 Cortodoxone
Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone).
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DC22479 Cortisone acetate
Cortisone acetate (Cortisone 21-acetate) is a synthetic glucocorticoid corticosteroid and corticosteroid ester.
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DC11048 Contilisant
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM.
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DC21345 Contezolid
Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.
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DC11164 Compound 919278
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK, does not inhibit the TNF-α-mediated nuclear translocation of p65 (RelA).
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DC22270 Compound 621433144
Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity.
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DC10933 Compound 3-110-22
Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E.
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DC7608 OXi-4503
Combretastatin A1 diphosphate OXi4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities.
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DC7813 Collagen proline hydroxylase inhibitor
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents.
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DC23785 Col 003
Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47.
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DC22149 COH-SR4
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling.
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DC10430 COH29
COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with an IC50 of 8 μM in KB cell.
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DC11081 Coblopasvir
Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection..
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DC22505 Cobimetinib R-enantiomer
Cobimetinib R-enantiomer (GDC-0973.
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DC24119 Cobimetinib racemate
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2..
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DC7104 CNX-1351
CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ.
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DC12103 CNT2 inhibitor-1
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.
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DC20346 CN-SAH
CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α..
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DC7009 CNS-7056
CNS 7056 is a new short-acting sedative/anaesthetic that acts on GABAA receptors in the brain.
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DC9370 CNP-AFU
CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU).
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DC12477 CN750
CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM.
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DC23508 CMPD167
CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM)..
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