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| Cas No.: | 1809151-56-1 |
| Chemical Name: | (5-(6-(4-(Trifluoromethyl)-4-(4-(trifluoromethyl)phenyl) piperidin-1-yl)pyridazin-3-yl)-1,3,4-oxadiazol-2-yl)methanol |
| Synonyms: | T 3764518;T3764518 |
| SMILES: | C(C1=NN=C(C2=NN=C(N3CCC(C(F)(F)F)(C4=CC=C(C(F)(F)F)C=C4)CC3)C=C2)O1)O |
| Formula: | C20H17F6N5O2 |
| M.Wt: | 473.379 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1; induces phosphorylation and activation of AMPK in HCT-116 cells, which led to blockade of downstream fatty acid synthesis and acceleration of autophagy; shows significant pharmacodynamic marker reduction (at 0.3mg/kg, bid) in HCT116 mouse xenograft model and tumor growth suppression (at 1mg/kg, bid) in 786-O mouse xenograft model; exhibits an excellent PK profile. |