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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC77295 (S)-NIFE
(S)-NIFE is a chiral derivatizing agent for proteinogenic amino acid analysis.
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DC77294 (S)-Isomyosmine
(S)-Isomyosmine is the S-enantiomer of Isomyosmine. Isomyosmine is a nitrate reductase inhibitor. Isomyosmine is a nicotine related alkaloid present in solanecea plants containing nicotine. Isomyosmine can be used for research of inflammation and age-related disorders.
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DC77293 (S)-Deoxy-thalidomide-Br
(S)-Deoxy-thalidomide-Br is a ligand for E3 ligase, used for the synthesis of PROTAC FHD-609.
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DC77292 (S)-(S,R,S,R)-AHPC-Me-N3
(S)-(S,R,S,R)-AHPC-Me-N3 serves as the E3 ligase ligand for PROTAC SMARCA2 degrader-32.
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DC77291 (Rac)-Roscovitine
(Rac)-Roscovitine ((Rac)-Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac)-Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac)-Roscovitine induces apoptosis in cancer cells. (Rac)-Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation.
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DC77290 (Rac)-RG108
(Rac)-RG108 (NSC401077), a DNMT1 inhibitor, inhibits DNA methyltransferases.
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DC77289 (Rac)-HA14-1
(Rac)-HA14-1 is the racemic form of HA14-1. DAO-dBET1 is a potent BRD4 degrader with a DC50 value of 277 nM in the presence of CoCl2. DAO-dBET1 inhibits hypoxia and Cath-L trigger with an IC50 value of 281 nM.
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DC77288 (rac)-dWIZ-1
WIZ-IN-1 (Example 2) is a Wiz inhibitor (DC50: 0.36 μM). WIZ-IN-1 can be used for research of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta- hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
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DC77287 (Rac)-BMS-1
(Rac)-BMS-1 is a racemate of BMS-1. (Rac)-BMS-1 can be used as a target protein ligand to synthesize D5B PROTAC.
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DC77286 (Rac)-1-Oleoyl lysophosphatidic acid
(Rac)-1-Oleoyl lysophosphatidic acid is an isomer of 1-Oleoyl lysophosphatidic acid sodium.
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DC77285 (R,S,S,S)-Orlistat
(R,S,S,S)-Orlistat is a stereogenic derivative of orlistat (tetrahydrolipstatin; THL). (R,S,S,S)-Orlistat inhibits three Mycobacterium tuberculosis lipid esterases, Ag85C (KI: 16.43 μM), Rv3802 (EC50: 16.2 nM), and Pks13-TE.
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DC77284 (R,S,S)-VH032-Me
(R,S,S)-VH032-Me is a ligand for E3 ubiquitin ligase. (R,S,S)-VH032-Me can be connected to the ligand for protein by a linker to form dTAGV-1-NEG.
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DC77283 (R)-Norfluoxetine
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine.
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DC77282 (R)-I-BET762 carboxylic acid
(R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid related compound, which inhibits Ca2+/calmodulin activated cyclic nucleotide phosphodiesterase with an IC50 value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent.
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DC77281 (R)-CYP3cide
(R)-CYP3cide ((R)-PF-4981517) is the R-isomer of CYP3cide.
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DC77280 (R)-AMG-193
(R)-AMG-193 is an isomer of AMG 193 for research in the cancer.
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DC77279 (E/Z)-Tapinarof
(E/Z)-Tapinarof ((E/Z)-WBI-1001; 3,5-dihydroxy-4-isopropylstilbene) is a broad-spectrum antibiotic. (E/Z)-Tapinarof has anti-bacterial, anti-fungal and anti-nematode activities.
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DC77278 (E/Z)-OSM-SMI-8
(E/Z)-OSM-SMI-8 is the racemate of OSM-SMI-8.
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DC77277 (E/Z)-NSC-687852
(E/Z)-NSC-687852 is a isomer of NSC-687852 derivative, which exhibits potent and selective inhibitory activities against CDK1/Cyclin B and GSK-3β (GSK-3β: IC50=0.8 nM; CDK1/Cyclin B: IC50=0.23 nM).
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DC77276 (E/Z)-HOIPIN-1
(E/Z)-HOIPIN-1 ((E/Z)-JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value >2.8 μM. HOIPIN-1 inhibits LUBAC-mediated NF-kB activation.
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DC77275 (E/Z)-CU-3
(E/Z)-CU-3 is a MCL-1 modulator. (E/Z)-CU-3 can be used to study hyperproliferative diseases, angiogenic diseases, cell cycle regulation diseases, autophagy regulation diseases, inflammatory diseases and/or infectious diseases.
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DC77274 (E/Z)-3PO
(E/Z)-3PO is a potent PFKFB3 inhibitor. (E/Z)-3PO can inhibit the glycolysis process, reduce the extracellular acidification rate, and inhibit the capillary tube formation, migration of endothelial cells, and the formation of aortic sprouts, thereby suppressing angiogenesis. (E/Z)-3PO is promising for research of diseases such as cancer, acute lung injury, pulmonary fibrosis, and atherosclerosis.
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DC77273 (E)-Cefodizime
(E)-Cefodizime ((E)-THR-221) is an antibiotic. (E)-Cefodizime can selectively bind to penicillin-binding proteins (PBPs) and inhibit the synthesis of the bacterial cell wall, thereby exerting antibacterial activity. (E)-Cefodizime is promising for research of various bacterial infectious diseases, such as for preoperative infection prophylaxis.
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DC77272 (E)-2-Hexadecenal
(E)-2-Hexadecenal (trans-2-Hexadecenal) is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways.
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DC77271 (6E)-SR 11302
(6E)-SR 11302 is a E-isomer of SR 11302. SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).
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DC77270 (4-Phenylphenoxy)phosphonic acid
(4-Phenylphenoxy) phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (KM: 86 μM). (4-Phenylphenoxy) phosphonic acid can be used in tuberculosis research.
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DC77269 (3S,5S)-Fluvastatin sodium
(3S,5S)-Fluvastatin sodium is the isomer of Fluvastatin sodium. Fluvastatin sodium is a first fully synthetic, competitive HMG-CoA reductase inhibitor.
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DC77268 (3aS,4R,9bR)-G-1
(3aS,4R,9bR)-G-1 is a highly selective G protein-coupled receptor GPR30 (GPER) agonist with a Ki value of approximately 7 nM. (3aS,4R,9bR)-G-1 activates rapid signaling pathways such as intracellular calcium mobilization and PI3K signaling through GPR30, promoting uterine epithelial cell proliferation and exerting antidepressant effects. (3aS,4R,9bR)-G-1 is promising for research of breast cancer and depression.
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DC77267 (2S,4R)-Teneligliptin
(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). (2S,4R)-Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R)-Teneligliptin is promising for research of type 2 diabetes.
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DC77266 (2R)-RXP470.1
(2R)-RXP470.1 ((2R)-RXP-470) is the (2R)-isomer of RXP470.1 on a cross-clade panel of 208-HIV-1 strains. BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency.
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