5-Hexynal (compound 3) is a PROTAC linker that can be used to prepare the PROTAC product iRucaparib-TP3.

5-Fluoro-L-tryptophan is a competitive vesicular glutamate transporter (VGLUT) inhibitor. 5-Fluoro-L-tryptophan is promising for research of diseases associated with the neurotransmitter systems.

5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.

4-Phenyl-1,2,3-thiadiazole is an CYP2B4 and CYP2E1 inhibitor. 4-Phenyl-1,2,3-thiadiazole inhibits the oxidation of 1-phenylethanol to acetophenone by CYP2B4 and CYP2E1.

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol. HA14-1 is a Bcl-2/Bcl-xL antagonist with an IC50 of approximately 9 μM against Bcl-2.

4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE, enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies.

4-Hydroxy-1-piperidinepropanamide is a PROTAC linker that can be used in the synthesis of PROTAC DDR1 degrader-1. Quinacainol dihydrochloride is an inhibitor for sodium current with an EC50 of 95 µM. Quinacainol dihydrochloride exhibits antiarrhythmic activity by affecting the electrophysiological properties of the heart.

DEG-35 is a CRBN-dependent, dual IKZF2 and CK1α molecule glue degrader, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. DEG-35 activates the p53 apoptosis pathway. DEG-35 can be used in the research for Acute Myeloid Leukemia (AML).

CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer.

AMPTX-1, a molecular glue, a potent and selective, reversibly covalent BRD9 degrader via recruitment of BRD9 to the E3 ligase DCAF16.

4-Desmethyl-2-methyl celecoxib (Compound 1g) is an orally active and selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 value of 0.069 μM. 4-Desmethyl-2-methyl celecoxib shows anti-inflammatory, analgesic, and antipyretic activities. 4-Desmethyl-2-methyl celecoxib can reduces the synthesis of prostaglandins. 4-Desmethyl-2-methyl celecoxib is promising for research of inflammatory diseases and pain-related diseases, such as rheumatoid arthritis and osteoarthritis.

4ʹ-Chloro deschloroalprazolam is a benzodiazepine compound and is a derivative of alprazolam.

4,6,4'-Trihydroxy-3'-methoxyaurone is an herbicide. At concentrations of 100 and 1000 µg/mL, 4,6,4'-Trihydroxy-3'-methoxyaurone is able to inhibit the growth of rape root and barnyardgrass seedlings1.

4-(Azidomethyl)-L-phenylalanine is an unnatural amino acid with an azidomethyl group at position 4 of L-phenylalanine. 4-(Azidomethyl)-L-phenylalanine can be used as a reporter for probing protein hydration through addition of an azide group.

3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (LPS).

3-O-Demethylfortimicin A (A-49759) is an aminocyclitol antibiotic with antibacterial activity. 3-O-Demethylfortimicin A is particularly effective against Gram-negative pathogens and staphylococcus.

3'-Hydroxy stanozolol is a major metabolite of the anabolic androgenic steroid Stanozolol.

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP trisodium inhibits DENV NS5 RdRp (IC50: 0.02 μM).

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM).

3-Aminobenzene-1,2-diol (compound C8) is a matrix metalloproteinase (MMP) inhibitor with IC50 values ​​of 20, 26, 16 and 16.3 μM for MMP-2, MMP-8, MMP-9 and MMP-14, respectively.

36R-D481 is a competitive and orthosteric antagonist of IL-36R, effectively inhibiting IL-36 signaling. 36R-D481 can inhibit IL-36α and IL-36γ but not IL-36β induced IL-8 release.

3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor Ezetimibe. DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

2F-PYR-Pip-spiro[3.3]heptane-acid is a PROTAC linker. 2F-PYR-Pip-spiro[3.3]heptane-acid can be used in the synthesis of PROTACs.

28-Aminobetulin is a pentacyclic triterpenoid and a derivative of the cholesterol biosynthesis inhibitor Betulin.

25(S)-27-Hydroxy cholesterol is a metabolite of CYP27A1 mediated cholesterol hydroxylation. 25(S)-27-Hydroxy cholesterol inhibits melanoma cell proliferation.

20α-Dihydro prednisolone is a metabolite of Prednisolone. Clonidine is an alpha 2-adrenergic agonist.

20-Hydroxyvitamin D3 (20(OH)D3) is a hydroxy metabolite of vitamin D3. 20-Hydroxyvitamin D3 functions as a ligand for vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor (LXR), and retinoic acid-related orphan receptor (ROR). 20-Hydroxyvitamin D3 inhibits cell proliferation, induces differentiation. 20-Hydroxyvitamin D3 can be used for inflammatory and autoimmune diseases study.

2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. 2002-G12 can be used in Alzheimer's research.

2-(3-Pyridyl)-benzimidazole is an Aminopyrine N-Demethylase inhibitor.

1-Boc-4-carboxymethyl piperazine is a PROTAC linker. 1-Boc-4-carboxymethyl piperazine can be used in the synthesis of PROTACs (e.g. PROTAC IRAK4 degrader-12 as the ligand for target protein.