Novel potent selective androgen receptor modulator (SARM)

Inhibitor of Janus kinases

Novel potent DNA-alkylating agent, inhibiting TBP/DNA interaction

Prodrug of Racemetirosine, an inhibitor of tyrosine 3-monooxygenase

Novel inhibitor of PI3Kβ and PI3Kδ, inhibiting growth of PTEN deficient breast and prostate tumor

Potent and selective antagonist of 5-HT2A receptors

Efficient stabilizer of Mahoney procapsids

Novel Antiviral agent for Enterovirus D68

Novel inhibitor of HDL uptake induced by overexpression of scavenger receptor BI (SR-BI)

Novel scavenger receptor class B type I blocker

Novel Potent and Specific Ligand of r(CCUG)exp, Targeting r(CCUG) Repeats in Myotonic Dystrophy Type 2, Facilitating Degradation by RNA Quality Control Pathways

Second-Generation GluN2C- and GluN2D-selective positive allosteric modulator (PAM) of the N-methyl-d-aspartate (NMDA) receptor

Novel microtubule destabilizer

Novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo

Natural disrupter of DNA replication and transcription via DNA intercalation, reducing oxygen intake and carbohydrate metabolism and the excitability of muscle fibers, inhibiting the drug efflux pump P-glycoprotein

Potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor

Modulator of specific GABAA receptors via the benzodiazepine site on the GABAA receptor

Novel photodynamic antitumor agent

Novel multitarget anti-AD agent, significantly increasing in adult neurogenesis and remyelination through Prox1/NeuroD1 and Wnt/β-catenin pathways, demonstrating beneficial effects in preclinical models of AD

Novel potent inhibitor of quorum sensing (QS) pathways, strongly blocking agr-type QS in S. aureus

Novel potent inhibitor of quorum sensing (QS) pathways, strongly blocking agr-type QS in S. aureus

Novel fluorescent molecular rotor for the selective detection of the hybrid-conformation 22AG G-Quadruplex

Novel Nav1.7 channel blocker (IC 50 at 3.5±1.5 μM). being efficacious on chronic pain in mice

Novel reactive oxygen species (ROS) inducer, showing significant cytotoxicity in pancreatic cancer cells

Novel Heme Oxygenase-1 Inhibitor (HO-1 IC 50 =0.27μM; HO-2 IC 50 =0.46μM)

Selective PAR1 negative allosteric modulator

Novel class of bright near infrared window II (NIR-II, 1,000 - 1,700 nm) probe, being successfully used to achieve high spatial and temporal resolution imaging of hind limb vasculature, lymphatic system, and small tumor metastasis, as well as precise NIR-

Novel inverse agonist of 5-HT6 receptor

Y2/Y5 Neuropeptide Y receptor agonist, reducing food intake in normal-weight and obese individuals and the plasma levels of the hunger-promoting hormone ghrelin

Novel BBB-permeable substrate of pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA), acting as a selective class I HDAC inhibitor