Novel potent and selective PDE8B/8A inhibitor

Selective dopamine D3/D2 receptor antagonist

Dose dependent inhibitor of multiple fibrotic genes

Novel γ-secretase inhibitor

First Inhibitor of PEX14-PEX5 Protein-Protein Interaction (PPI) with Trypanocidal Activity

Novel allosteric inhibitor of E. coli Hsp70 (DnaK) and human Hsp70 proteins

Non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor

Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation

Agonist of dopamine receptor subtypes D1 and D2

Broad-spectrum virus- and host-targeting peptide, inhibiting coronaviruses and other respiratory viruses

ApoA-I/HDL mimetic peptide, efficiently crossing the blood-brain barrier and modulating amyloid beta distribution between brain and plasma

Innate defense regulator, target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model

Inhibitor of calcium-dependent complex formation with p53 [(Ca)S100B-p53] in malignant melanoma (MM), restoring p53 tumor suppressor activity in vivo

Novel potent and broad-spectrum anti-influenza A virus (anti-IAV) activities with low risk of inducing drug resistance

Antibiotic, a natural penicillin, synthesized in vitro by incubating (S-octanoyl)glutathione, 6-APA and AT

Mycotoxin with antibiotic and carcinogenic activity

Antineoplastic agent, alkylating and crosslinking DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis

Novel caged glutamate

Cyclooxygenase Inhibitor and Prostagladin Synthase Inhibitor

Activator of SHIP-1

Novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML)

Novel Potent PD-L1 Inhibitor (IC50 1.8 nM), binding to human PD-L1 (hPD-L1) with a KD value of 3.34 nM, without showing any binding to hPD-1, blocking PD-1/PD-L1 interaction with an EC50 value of 375 nM

Novel PROTAC dual inhibitor and degrader of PD-L1, inhibiting PD-1/PD-L1 interaction with IC50 of 39.2 nM in an HTRF binding assay

Novel PD-L1 degrader, showing 66.99% degradation activity at 20 μM with no calcium blocking effect, strengthening the T cell-mediated killing of tumor cells

Protein disulfide isomerase (PDI) inhibitor

Novel Peptide Deformylase (PDF) Inhibitor

Novel inhibitor of melanogenesis

Novel Potent, Selective, and Orally Bioavailable Inhibitor against Phosphodiesterase-9 (PDE9)

Novel selective PDE9 inhibitor with strong antioxidant activity, inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

Novel cell-permeable PDE7 inhibitor, targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element binding protein (CREB) pathway, exerting neuroprotection in an Alzheimer's disease (AD) model