VU0155069|CAS 1130067-06-9|DC Chemcals

Cas No.:	1130067-06-9
Chemical Name:	VU0155069
Synonyms:	CAY10593;VU 0155069;(S)-N-(1-(4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide;compound 69 [PMID: 19136975];VU0155069;N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide;N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide;GTPL8782;BDBM50258182
SMILES:	ClC1C=CC2=C(C=1)NC(N2C1CCN(C[C@H](C)NC(C2C=CC3C=CC=CC=3C=2)=O)CC1)=O
Formula:	C₂₆H₂₇ClN₄O₂
M.Wt:	462.971184968948
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM); sensitizes MCF7 and MDA-MB-231 breast cancer cells to doxorubicin-induced cytotoxicity, suppresses growth of colorectal cancer activated by the Wnt/β-catenin and PI3K signaling pathways.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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