Second-Generation RET/VEGFR2 Inhibitor

Natural inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana

Natural inhibitor of the allosteric regulation of Hsp70

Novel potent LRRK2 inhibitor

Novel potent notum inhibitor (OPTS IC50 3.6nM; TCF-LEF EC50 220nM), showing good plasma exposure and reasonable CNS penetration

Novel potent inhibitor of notum carboxylesterase activity

Natueal sigma receptor agonist, attenuating cytokine release associated with SARS-CoV-2, also being used as anti-malarial, anti-stroke and cough-suppressant

Controllable nitric oxide (NO) donor, releasing NO triggered by photoinduced electron transfer (PeT)

Secondary metabolite from the myxobacterium Sorangium cellulosum, acting as a potent HCV inhibitor, Ebola virus (EBOV) entry inhibitor, and a potassium channel inhibitor

Steroidal progestin used in veterinary medicine to control estrus and ovulation in cattle

FAUC-365 analog

Novel red-light-controllable nitric oxide (NO) releaser

Novel human epidermal growth factor receptor-2 (HER2) inhibitor; Spermatocide

Neutral, nonandrogenic, progesterone-like profile progestin

Steroidal progestin

PPARalpha agonist and EC 3.5.1.23 (ceramidase) inhibitor

Neuropeptide, acting as a endogenous ligand for the nociceptin receptor (NOP, ORL-1)

Marine natural nocazine family member; Standard used in nocazine biosynthetic parthway studies

Nocazine family member

Natural Inhibitor of an Oncogenic RNA, targeting RNA folds in the nuclease processing site in the oncogenic, noncoding microRNA-18a, selectively inhibiting nuclease processing in vitro and in prostate cancer cells and triggering apoptosis

The universal precursor of the nocardicins

Moderate antibiotic agent against a broad spectrum of gram-negative bacteria

Novel non-nucleoside reverse transcriptase inhibitor (NNRTI)

Novel potent alkynyl bisubstrate inhibitor of nicotinamide N-methyltransferase (NNMT)

Iminosugar, binding to the active site of lysosomal beta-glucosidase and stabilizing the proper folding for the catalytic form, acting as a chemical chaperone that facilitate transport and maturation of acid beta-Glu

Novel selective histamine H3 antagonist

Novel inhibitor of autophagy, protecting cardiomyocytes against hypoxia/reoxygenation injury

Novel Potent and Highly Selective, Long-Acting, Peptide-Based Cholecystokinin 1 Receptor (CCK-1R) Agonist

Novel JAK2 inhibitor, displaying significant tumor growth inhibition in SET-​2 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile

Novel selective and orally bioavailable MPS1 inhibitor