Novel inhibitor of E3 ligase activity of cIAP1, antagonizing c-MYC by stabilizing MAD1 protein in cells

Novel chymase inhibitor, exhibiting concentration-dependent chymase inhibitory activity

Novel Non-peptide GLP-1R Agonist, adopting a unique binding mode with a more open receptor conformation at the extracellular face

Novel inhibitor of superoxide anion (O2(-)) generation; Inhibitor of phospholipase D activation; Modulator of immune cell migration via RhoA activity inhibition; Inhibitor of Rac2 activation in stimulated neutrophils

Novel inhibitor of 6-hydroxydopamine induced apoptosis in SH-SY5Y cells via mitochondria protection and NF-κB modulation

Novel potent BMP potentiator with osteogenic efficacy, enhancing canonical BMP outputs at the expense of TGFβ-Smads in an unprecedented manner

Potent and selective partial agonist of ecdysone receptor (EcR)

Natural phytosterol, showing antidiabetes activities

Antioxidant; Aldose reductase inhibitor

Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors

Novel Potent Fms-like Tyrosine Kinase 3 Internal Tandem Duplications (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia

Potent and selective FLT3 inhibitor

Novel potent and highly selective irreversible Brutons tyrosine kinase (BTK) inhibitor, inhibiting BTK Y223 auto-phosphorylation

Hydrophilic prodrug of CHM-1

Serotonin transporter substrate

Sympathomimetic agent, facilitating the release of catecholamines, especially noradrenaline and dopamine, from nerve terminals in the brain and also inhibiting their uptake

Widely used biocidal agent

Antiviral and antifungal agent

Novel potent inhibitor of HIV-1 integrase

Novel Potent and Selective Chikungunya Virus Envelope Protein Inhibitor

Potent, long-acting, and selective muscarinic M3 receptor antagonist

Potent, tissue-selective estrogen receptor modulator

Novel acetylcholinesterase inhibitor

Novel dual inhibitor of cholinergic dysfunction and amyloid deposition for AD treatment, penetrating the blood-brain barrier (BBB) and enhancing the cerebral acetylcholine level

Novel potent and orally active ChemR23 inhibitor (IC 80 = 12 nM), showing a long-acting effect in cynomolgus monkeys

Inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase

Novel inhibitor against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum

Novel intracellular chelator, disrupting iron homeostasis in bacteria

Novel potent and selective kynurenine mono-oxygenase (KMO) inhibitor

The desmethyl precursor of CHDI-180R which is a first-in-class high-affinity PET imaging ligand specific for mHTT aggregates