Ras destabilizer, targeting the Wnt/ß-catenin pathway and inhibiting development of metastatic colorectal cancer

Novel Preferable Phosphodiesterase 4B (PDE4B) Inhibitor, Decreasing Cocaine-Mediated Reward Properties in Vivo

Novel neuroprotectant, inhibiting Kv2.1-syntaxin molecular interaction

Potent Kv1.5 inhibitor

Novel protein farnesyltransferase inhibitor

Novel potent and selective inhibitor of Hsp90β

Novel selective DYRK1A inhibitor

Hypoxic cell radiosensitizer

Thyroid hormone receptor β (TRβ) selective agonist

TXA2/prostaglandin endoperoxide receptor antagonist

Potent and selective inhibitor of ABHD6

Novel modulator of kinesin spindle protein (KSP)/Eg5, activating KSP-catalyzed ATP hydrolysis in the absence of microtubules yet inhibiting microtubule-stimulated ATP hydrolysis by KSP

Novel, highly potent, and metabolically stable peptide inhibitor of syntenin, Inhibiting Glioblastoma

Novel inhibitor of transcriptional activity in Chlamydia trachomatis

Ligand of the sigma receptor

Ligand of the sigma receptor

Selective ligand of the sigma-1 receptor

Novel inhibitor of the permeability transition pore (PTP)

Novel Potent and Selective VIPR2 Antagonist, Counteracting Cognitive Decline in a Mouse Model of Psychiatric Disorders

Novel highly selective β3-adrenoceptor agonist being developed for the treatment of diabetes and obesity

Highly potent and selective antagonist for the AMPA receptors, exhibiting good neuroprotective effects in vivo

Novel neutrophil elastase (NE) inhibitor, decreasing expression of TGF-ß Signal Related Genes

Topo II inhibitor, exhibiting cytotoxic effects against tumour cells

Potassium channel opener

Novel potent, non-toxic, blood-brain barrier crossing, α5-GABA A R preferring ligand, enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, c

Selective novel inhibitor of c-Met receptor tyrosine kinase with anticancer activity.

Novel potent multi-kinase inhibitor, targeting Ron, Flt3 and TrkA as well as c-Met

Novel stabilizer of the KRAS4b-PDEδ complex, decreasing the proliferation of colorectal cancer cells, and increasing apoptosis via decreased activation of oncogenic KRAS4b signaling

Novel specific inhibitor of oncogenic KRAS4b signaling, stabilizing the KRAS4b-PDEδ complex and remarkably decreasing tumor size and triggered apoptosis of tumor cells

Novel irreversible inhibitor of KRAS(G12C)