Nucleosidic antibiotic

Novel dual μ-opioid and nociceptin receptor partial agonist (K i = 16.49 and 3.67 nM, respectively)

High affinity, selective alpha3beta4 nAChR ligand

Novel potent and selective partial agonist of human and rat α3β4 nicotinic cholinergic receptors

Novel NOP receptor-mu opioid receptor ligand

The First Small-molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa and Nociceptin Opioid Receptors.

Novel inhibitor of αSyn fibrillization, blocking fibril growth and suppressing A53T αSyn neurotoxicity

Natural endogenous inhibitor of nitric oxide synthases (NOS), also inhibiting arginine transport and increasing oxygen free radicals, mitochondrial dysfunction and transforming growth factor beta (TGFβ) expression, exhibiting a strong association with car

Inhibitor of HIV-reverse transcriptase activity

Novel AKAP1/PKA modulator, inducing UCP1 expression and thermogenesis

Novel anti-Alzheimer’s agent, inhibiting amyloid β aggregation, β-secretase, and tau aggregation

Novel near-infrared (NIR) probe for imaging β-amyloid (Aβ) plaques or Tau tangles

Novel potent anticancer agent, inhibiting the growth of CRC bulk and sensitized FOLFOX-resistant cells

Natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent in vivo antitumor activity in an SW1990-cell-induced x

Natural luciferase inhibitor

Natural inhibitor of pollen development in Arabidopsis thaliana, also inhibiting dihydroxy-acid dehydratase (DHAD)

Natural antineoplastic agent, targeting cathepsin and inducing autophagy effects in breast cancer cells

Novel cholecystokinin antagonist

Novel cholecystokinin antagonist

Selective antagonist for the cholecystokinin receptor CCKA

Novel potent Aspergillus hyphal growth inhibitor

Novel long-acting muscarinic antagonist (LAMA), showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide

Novel tropomyosin-related kinase A (TrkA) inhibitor for the oral treatment of pain due to osteoarthritis of the knee

Novel dual A2A/A1 AR antagonist

Novel antifungal agent against Aspergillus isolates

Selective progesterone receptor modulator

Novel slow-onset, tight binding, potent asparagine synthetase (ASNS) inhibitor

Novel potent GPR17 agonist

Novel Permanently-charged Sodium Channel Blocker, Showing Robust Efficacy, a Rapid Onset and Long Duration of Action

Novel, Potent, Selective, and Direct Acid Sphingomyelinase (ASM) Inhibitor with Antidepressant Activity