Unique signaling molecule used in quorum sensing

Novel autophagy inhibitor, targeting mitochondrial complex I directly, leading to the potent inhibition of mitochondrial respiration as well as autophagy

Novel DNA damage inducer during G0/G1, S, and G2 cell cycle phases via a mechanism unique from other DNA damaging agents

Novel potent ATP-competitive inhibitor of Aurora A/B/C (5.6/18.4/24.6 nM)

Novel small 4 integrin antagonist, preventing the development of experimental colitis in mice.

Potent inhibitor of HCV RdR

Novel inhibitor of AChE, suppressing Aβ aggregation, protecting Caenorhabditis elegans against Aβ- and 6-OHDA-induced neurotoxicities dose-dependently

Natural antibiotic

Novel AURKA inhibitor, reducing clonogenicity, arresting the cell cycle at the G2/M phase, and inducing caspase-mediated apoptotic cell death in HCT116 human colon cancer cells

Potent inhibitor of HCV RdR

Novel inhibitor of JAK/STAT signaling, inhibiting both constitutive and interleukin-6-induced STAT3 phosphorylation, selectively affecting cell viability only of cancer cells harboring aberrant JAK/STAT signaling

Novel selective Autotaxin (ATX) inhibitor

Novel Potent Autotaxin (ATX) Ligand

Novel potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor

Novel potent and selective dual inhibitor of MDM2 (Ki = 0.9 nM) and MDMX (Ki = 7 nM)

Novel Potent Dual Inhibitor of MDM2 and MDMX (Ki =1 nM)

Natural potent apoptosis inducer in U937 cells, inducing caspase-3 processing, PARP, and DNA fragmentation

Novel antitimor agent, exhibiting superior anti-proliferative activity, excellent chemo-sensitizing activity against pancreatic cancer in vitro and in combination with Gemcitabine

Novel potent inhibitor of nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1)

Novel non-toxic contrast agent for micro-CT imaging

Novel inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets

Novel selective A2BR antagonist

Potent JAK2 inhibitor

Selective ß1 receptor antagonist

Novel ROS generator, permeating mycobacteria to reliably enhance endogenous ROS including superoxide radical

Potent cytotoxic agent for both prostate cancer and melanoma

Hydrogen sulfide-releasing cyclooxygenase inhibitor

Novel degrader of MTH1 fusion proteins for use within the aTAG system

Novel inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies

Novel selective nociceptin receptor (NOP) agonist