Novel modulator of acetylcholine receptor function, promoting the in vitro relaxation of β2-adrenoreceptor desensitized tracheas

Novel, Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Modulating Brain Inflammation In Vivo

Natural Suppressor of MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades

Novel inhibitor of inositol-requiring enzyme 1 (IRE-1), also inhibiting G protein-coupled receptor kinase 6 (GRK6)

Novel angiogenesis inhibitor, directly binding to acid ceramidase 1 (ASAH1)

Selective inhibitor of aurora kinases (AKs)

Novel Receptor-interacting Protein Kinase 2 (RIP2) Inhibitor

Novel GPR40 agonist

Novel SHIP2 inhibitor, increasing Akt phosphorylation, glucose consumption, and glucose uptake in L6 myotubes, specifically upregulating the GLUT1 gene

Novel Foxo1 inhibitor, exerting anti-diabetic and anti-hypertriglyceridemic effects by improving blood glucose and triglyceride metabolism at the gene expression level

Second-generation potent orally-active thrombopoietin (TPO) receptor agonist

Novel GPR119 agonist, potentiating insulin secretion from rat islets and having potent anti-diabetic effects in ICR and diabetic db/db mice

Potent factor Xa inhibitor with significant oral anticoagulant activity

Inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake, significantly restoring decreased insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively

Inhibitor of D-amino acid oxidase (DAAO)

Novel Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers

Non-steroidal selective estrogen receptor modulator (SERM)

Inhibitor of the inflammatory responses via NF

The first human arylsulfatase A reversible inhibitor, impairing mouse oocyte fertilization

Selective alpha-7 agonist

Novel potent and selective BRAF inhibitor

Novel selective estrogen receptor degrader (SERD), inducing regression in a tamoxifen-resistant breast cancer xenograft

Novel dual inhibitor of the fatty acid amide hydrolase (FAAH) and the cyclooxygenase (COX) enzymes

Regulator and promotor of immune functions, enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function

Natural inhibitor of recombinant purified ClpXP and ClpYQ AAA+ proteases, exhibitung potent antibacterial activity against H. pylori, including multidrug-resistant strains

Selective ecto-ATPase inhibitor, preventing metabolism of P2 purinoceptor agonists

P2T (P2YADP) purinoceptor antagonist

Novel inhibitor of Ark1, the fission yeast member of the conserved Aurora kinase family

Novel selective inhibitor of PREP, displaying great selectivity over FAP, while also not inhibiting the DPPs.

Potent tumor-homing tripeptide, targeting heat shock protein 70 (HSP70)