Novel potent MtbCoaBC inhibitor (IC50: 0.08 µM)

Metabolite of soy isoflavones

Metabolite of soy isoflavones

Metabolite of soy isoflavone; Antioxidant

Novel FUdR prodrug. possessing a better tumor inhibition rate and a better metabolic stability than FUdR through a ATB0, -mediated prodrug approach

Novel O-GlcNAc transferase (OGT) inhibitor, inducing dose- and time-dependent decreases in O-GlcNAc levels

Blocker of the formation of the FAK/Mdm-2 complex; subsequently, activating p53 and caspase-8 and leading to increase detachment and apoptosis in breast and colon cancers

Natural inhibitor of hedgehog (Hh) signal transduction, diminishing characteristics of cancer stem cells, leading to decreasing production of the Hh target proteins BCL2, PTCH1, and BMI1

PhIP metabolite

Inducer of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells

Novel highly potent nonsteroidal antiandrogen (NSAA)

Neutral allosteric site ligand of the metabotropic glutamate receptor subtype 5 (mGlu5), blocking the effects of both the allosteric antagonist MPEP and potentiator CDPPB

Novel potent δ-selective allosteric modulator, displayed at least 60-fold selectivity for α4β1δ over α4β1γ2 receptor subtypes, Ki(α4β1δ

Natural proangiogenic agent, downregulating the cellular uptake of all- trans-retinoic acid (atRA) under hypoxia

Melatonin analogue, selectively binding on MT3 subsites

Active metabolite of diclofenac, targeting COX and CaMKIIα hub domain

Morin isomer, antioxidant

Metabolite of dantrolene

Novel potent and selective G protein-biased 5-HT 7 R Antagonist, significantly reducing self-grooming duration time to the level of wild-type mice

Novel selective 5-HT 2C agonist with >300-fold functional selectivity over 5-HT 2B and >70-fold functional selectivity over 5-HT 2A , reducing food intake in an acute rat feeding model

Serotonin metabolite, systemically inhibiting RAS/MAPK signaling in different organs of C. elegans

Novel palladium-activated 5-FU prodrug, being completely innocuous to cells and highly resistant to metabolization by primary hepatocytes and liver S9 fractions (the main metabolic route for 5-FU degradation), and rapidly converted into 5-FU in the presen

Rare base found in mammalian DNA, having functional roles in DNA that go beyond being a demethylation intermediate

HIV-1 integrase inhibitor

Novel HIV-1 integrase inhibitor

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.14 µM

Novel potent δ-selective allosteric modulator, Ki(α4β1δ) 0.06 µM

Brominated luciferin, being more cell permeant than luciferin

Adenosine kinase inhibitor

Novel Inducer of G2/M arrest, Apoptosis and Autophagy in Cancer Cells