GW 842166X is a cannabinoid receptor 2 (CB2) agonist potentially for the treatment of inflammatory pain.

Idremcinal is a motilin receptor agonist potentially for the treatment of gastritis

AIM-102 is nonsteroidal, immune modulating, anti-inflammatory drug potentially for the treatment of allergic asthma

SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.

Bepafant, also known as WEB-2170 and STY-2108, is a platelet activating factor (PAF) antagonist potentially for the treatment of asthma. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was absent. Bepafant may produce significant anti-inflammatory effects.

Indole-3-propionic acid, also known as IPA and SHP-622, is a beta-amyloid protein neurotoxicity inhibitor potentially for the treatment of Friedreich's ataxia. The administration of IPA significantly decreased the level of 4-hydroxy-2-nonenal, a marker of lipid peroxidation, in ischemic hippocampal homogenates compared with that in the vehicle-treated ischemic groups at various times after ischemia/reperfusion. In addition, immunostaining for 8-hydroxy-2'-deoxyguanosine showed DNA damage in pyramidal neurons in the ischemic CA1 was significantly lower in the IPA-treated ischemic groups than in the vehicle-treated ischemic groups. IPA may be used as a pharmacological agent to protect against iron-induced oxidative damage to membranes and, potentially, against carcinogenesis.

Histapyrrodine hydrochloride is a bioactive chemical.

Lupulon, also known as Lupulone, is a beta-acid that has been found in the hop plant, H. lupulus, and has diverse biological activities, including antibacterial, antioxidant, and anticarcinogenic properties. Lupulone is active against B. subtilis and S. aureus as well as T. b. brucei and L. m. mexicana. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and reduces proliferation, migration, and capillary tube formation in human umbilical vein endothelial cells (HUVECs). Lupulone also activates the extrinsic apoptotic death pathway in SW480 and SW620 colon cancer cells.

Spongouridine is a deamination metabolite of Cytarabine (GLXC-07791).

Undecylprodigiosin is a classical cytotoxic immunosuppressant, suppressing immune functions and inhibiting DNA synthesis.

CAY10404 is one of the most selective inhibitors of COX-2 over COX-1.

ENMD-1068 HBr is a novel antagonist of Proteinase-Activated Receptor 2 (PAR-2).

1,3-Dicaffeoylquinic acid is an inhibitor of taste receptors.

IWP-12 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT).

gamma-DGG is a broad spectrum glutamate receptor antagonist.

Etilevodopa HCl is a prodrug of levodopa with greater gastric solubility and significant brain penetration.

MitoB is a novel exomarker of mitochondrial hydrogen peroxide.

Spiperone HCl is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist.

FPL-55712 is a CysLT1 leukotriene receptor antagonist.

PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors.

A3 HCl is an inhibitor of PKA, PKC, and casein kinase I and II, and MLCK.

Amperozide HCl is a 5-HT2/D2 antagonist, inhibiting nomifensine-induced hyperlocomotion and human FAAH.

SC-53116 HCl is a psychoactive agent, increasing in production of serotonin in central nervous system tissue.

RP-106 is a selective, potent, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3.

(-)-MDO-NPA HCl is an orally effective long-acting agent active at central dopamine receptors, and analogous aporphines.

U-69593 is a selective kappa opioid receptor agonist.

BCI hydrochloride is an allosteric inhibitor of Dusp6, acting within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding.

SB-505124 HCl is an inhibitor of activin receptor-like kinase (ALK) 5.

P18IN011 is a novel p18(INK4C) inhibitor.

NMIA, also known as N-Methylisatoic Anhydride, is an RNA SHAPE reagent.