CP 100356 is a high affinity P-glycoprotein (P-gp) inhibitor (Ki values are 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms). Inhibits calcein-AM uptake in MDR1-transfected MDCKII cells (IC50 = 0.5 μM) and prazosin transport in BCRP-transfected MDCKII cells (IC50 = 1.5 μM). CP 100356 modulates multidrug resistance.

Clorsulon is antihelminthic compound that is a potent fasciolicide. Clorsulon targets phosphoglycerate mutase and phosphoglycerate kinase. Clorsulon also discriminates between highly similar host and parasite enzymes.

Clorindione is a long acting oral anticoagulant.

Clinafloxacin is an antimicrobial antibiotic that displays broad-spectrum antibacterial activity against Gram-positive, Gram-negative, and anaerobic pathogens by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 μg/ml) as well as topoisomerase IV (IC50 = 1.62 μg/ml).

Climbazole is a potent inducer and inhibitor of P450-dependent drug metabolizing enzymes, which is also used as antifungal and antidandruff agent.

Cianopramine hydrochloride is a bio-active chemical.

CGP-77675 is a potent and selective Src family kinase (SFK) inhibitor. CGP-77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). The dual inhibition of Src and GSK-3 signaling by CGP 77675 and CHIR 99021 was found to maintain mouse embryonic stem cell (mESC) self-renewal and pluripotency marker expression as efficiently as the dual inhibition of MAPK and GSK-3 by PD 0325901 and CHIR 99021.

CGP-54626 is a selective antagonist of the GABAB receptor with an IC50 value of 4 nM.1 It can be used to investigate the role of GABAB receptors in neurological signaling.

Carbenicillin disodium salt is a penicillin-derived, β-lactam antibiotic which inhibits the synthesis of peptidoglycan, a key component of the bacterial cell wall. Unlike most β-lactams, carbenicillin disodium is limited to primarily gram negative bacteria including Pseudomonas aeruginosa and common enteric species. In plants Carbenicillin was investigated for its effects on morphology and growth of Beta vulgaris, Capsicum annuum and Glehnia littoralis roots. Carbenicillin was noted to inhibit root elongation while promoting root branching in contrast to Ampicillin.

Bucinnazine Hydrochloride, also known as AP-237 HCl, is an analgesic.

BIIE-0246 is a potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y2 receptor. BIIE-0246 displays > 650-fold selectivity over Y1, Y4 and Y5 receptors.

Bentazepam is a thienodiazepine which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around 2,5 hours after oral administration.

Barban is a selective herbicide for wild oats.

AZD5423 is a nonsteroidal glucocorticoid by AstraZeneca used to treat respiratory diseases and in particular chronic obstructive pulmonary disease.

AZ-11645373 is a potent and selective human P2X7 antagonist that is completely without effect at all other P2X subtypes. It also inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release.

Avridine is a potent synthetic adjuvant that can induce arthritis. It is an immunomodulator and interferon-inducing agent.

Arundic Acidis is an astrocyte modulating agent, in acute ischemic stroke. It is a therapeutic agent for the treatment of neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease.

AR-9281 is a soluble epoxide hydrolase (s-EH) inhibitor potentially for the treatment of hypertension and type 2 diabetes.

Anecortave Acetate is an angiostatic steroid used for proteomics research.

AM-2233 is a highly potent full agonist for the cannabinoid receptors. It was developed as a selective radioligand for the cannabinoid receptors and has been used as its 131I derivative for mapping the distribution of the CB1 receptor in the brain. AM-2233 was found to fully substitute for THC in rats, with a potency lower than that of JWH-018 but higher than WIN 55,212-2.

AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2.

AM-1235 is a drug that acts as a potent and is selective agonist for the cannabinoid receptor CB1.

AM 114 is a proteasome inhibitor. It is an inhibitor of chymotrypsin-like activity of the 20S proteasome. Also, AM-114 displays anticancer activity, inhibits cell growth in human colon cancer HCT116 p53+/+ cells.

Alatrofloxacin Mesylate is the parental prodrug of Trovafloxacin, a broad-spectrum antibiotic.

Abafungin is a broad-spectrum antifungal agent.

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). It blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes and suppresses neuroinflammation in a mouse EAE model. MSC 2032964A is orally bioavailable and brain penetrant.

Aphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus, Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses (vaccinia and herpesviruses) and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.

Prostratin is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). While prostratin was originally isolated and identified as a new phorbol from species of the genus Pimelea (Thymelaceae) in Australia, the antiviral activity of prostratin was discovered during research on the traditional knowledge of Samoan healers in Falealupo village by ethnobotanist Paul Alan Cox and a team at the U.S. National Cancer Institute. Samoan healers use the mamala tree to treat hepatitis. Research indicated that prostratin has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells. As a modulator of Protein Kinase C, it has been shown to exhibit promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. In 2015, study showed that orally administrated prostratin repressed human pancreatic tumor. (Source: https://en.wikipedia.org/wiki/Prostratin). (Last update: 4/1/2016).

MI-192 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC2 (IC50 = 30 nM) and HDAC3 (IC50 = 16 nM) over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 μM, respectively).

2-Phospho-L-ascorbic acid trisodium salt is a stable ascorbic acid derivative used in cell culture. In combination with FGF-2, it maintains differentiation potential in bone marrow-derived mesenchymal stem cells (MSC) through increased expression of HGF. L-Ascorbic acid 2-phosphate may be used in cell differentiation and tissue engineering applications. 2-Phospho-L-ascorbic acid trisodium salt also exhibits synergistic protection of hMSCs under oxidative stress in combination with N-acetylcysteine. Asc-2P is used in studies of gene repression, such as the repression of dihydrotestosterone-induced dickkopf-1 expression. AA2P has been shown to increase myogenin gene expression and promote differentiation in L6 muscle cells.