Novel cyclooxygenase-1 (COX-1)-selective inhibitor

mGlu1 positive allosteric modulator (PAM)

Novel potent mGlu4 PAM with an attractive DMPK profile, and robust efficacy in preclinical Parkinsons disease model, haloperidol-induced catalepsy (HIC)

Potent and selective mGlu5 negative allosteric modulator (NAM)

Novel potent and selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM)

Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Selective orthosteric M1 antagonist

Highly selective muscarinic M1 PAM

Novel negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety

Novel mGlu4 positive allosteric modulator (PAM)

Novel M4 muscarinic acetylcholine receptor modulator

Highly M1-selective antagonist

Allosteric modulator of the M2/5 muscarinic acetylcholine receptor

Novel positive allosteric modulator (PAM) of mGlu4

Muscarinic antagonist; inhibiting ACh-induced Ca(2+) responses at rat M(1-5) receptor subtypes

Highly potent non-MPEP site metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM)

Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 5 (mGlu5)

Potent noncompetitive antagonist of Metabotropic_glutamate_receptor_5>metabotropic glutamate receptor 5 (mGlu5)

Potent and specific PAM for the rat mGluR5 receptor

Novel Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5, Revealing Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 5 (mGlu5)

Allosteric modulator of the M1 muscarinic receptor

Selective modulator of G protein-coupled inward rectifier K (GIRK)

Novel non-MPEP site metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs)

Novel selective agonist of TLR8

Sphingosine kinase (SphK) inhibitor, having modest SphK2-selectivity

Novel Promoter of Neuronal Branching Via Transcellular Activation of the Focal Adhesion Kinase (FAK) and the ERK1/2 Signaling Pathway In Vitro

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS)

Novel Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Inhibitor of the catalytic activity of VRV-PL-VIIIa, strongly inhibiting the hemolysis of red blood cells and VRV-PL-VIIIa-induced myotoxicity and lung hemorrhage in mice