Natural Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels, acting on the channel as either an agonist or antagonist depending on the nature of the electrophysiological stimulation protocol

Antitumor agent

Serotonin-norepinephrine reuptake inhibitor (SNRI); Antidepressant

Activator for Proprietary Gene Therapy Promoter System

Potent, Vascular Endothelial Growth Factor Receptor-​2 (VEGFR-2) Tyrosine Kinase Inhibitor

Novel Aurora kinase inhibitor

Novel nonsecosteroidal vitamin D receptor (VDR) modulator, enhancing pancreatic cancer therapy through remodeling of the tumor microenvironment by combination with gemcitabine

Novel nonsecosteroidal vitamin D receptor (VDR) modulator, enhancing pancreatic cancer therapy through remodeling of the tumor microenvironment by combination with gemcitabine

Novel nonsecosteroidal vitamin D receptor (VDR) modulator, enhancing pancreatic cancer therapy through remodeling of the tumor microenvironment by combination with gemcitabine

Novel potent and selective CA IX inhibitor

Novel potent and selective CA IX inhibitor

Novel selective inhibitor of the γ-class enzyme of bacteria Vibrio cholerae A (VchCAγ)

Novel non-nucleoside inhibitor of HCV RNA-dependent polymerase

Novel inhibitor of VDAC1 oligomerization and apoptosis

Novel potent inhibitor of VDAC1, directly interacting with purified VDAC1 and reducing its channel conductance

Novel potent TLR‐4 activation inhibitor, attenuating the expression of fibrosis hallmark genes collagen, fibronectin (FN) and transforming growth factor β (TGF‐β) in kidneys and improved albumin/creatinine ratio with higher efficacy

Natural inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL 2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively, also inhibiting PKC β1 activity with an IC50 value of 36.2 μM

Partial α4ß2 nicotinic receptor agonist and α7 full agonist

Novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice

Novel selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability

Novel prodrug of luciferin to mimic the transport and activation of valacyclovir, , being a robust and functional determinant of VACVase activity

Natural pseudo-aminosugar

Prodrug of ganciclovir for treatment of cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant

Orally acting antinociceptive muscarinic agonist

Selective 5-HT2C receptor full agonist

Specific inhibitor of tissue Kallikrein>kallikrein

Novel potent inhibitor of FGFR4 kinase activity

Novel Mycobacterium Tuberculosis VapC-Activating Stapled Peptide, successfully penetrated Mycobacterium smegmatis cell membranes and exerted bactericidal activity at a minimum inhibitory concentration that inhibited 50% of the isolates (MIC50) < 6.25 μM

Novel Long Residence Time Superior Inhibitor of the Vasopressin V2 Receptor

Non-immunosuppressive immunophilins ligand, demonstrating enhanced neuroregeneration in the peripheral nervous system and CNS