Novel Rho kinase inhibitor

Novel inhibitor of mitogen and Stress-Activated Kinases 1 (MSK1)

Novel CXCR2 selective antagonist, inhibiting ex vivo neutrophil activation and ozone-induced airway inflammation in humans

Novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor

Potent and selective dopamine D3 receptor antagonist

Novel TRPV4 blocker

AntiMycobacterium tuberculosis agent

Selective p38a kinase inhibitor, inhibiting Brd4

Selective dopamine D3 receptor antagonist

Nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reducing angiogenesis and VEGF expression

Novel selective mTOR inhibitor

Selective 5-HT7 receptor antagonist

Selective 5-HT2C_receptor>5-HT2C inverse agonist

Inhibitor of p38 MAPK

Potent and selective agonist for the human ß3-adrenoceptor

Potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase

Dual ETA and ETB receptor antagonist

Selective, active-site-directed 14 kDa PLA2 inhibitor, totally inhibiting LT and PAF formation, while prostanoid formation was not altered

Novel neuroprotective agent, suppressing abnormal tau protein aggregation

Novel reversible covalent inhibitor of the cyclin-dependent kinase 5 (Cdk5)-mediated phosphorylation of PPARγ at Ser245, a key factor in the insulin-sensitizing effect of PPARγ-targeted drugs

PPARγ covalent ligand

Subtype-selective α4β2 nicotinic acetylcholine receptor partial agonist

Inhibitor of H274Y and N294S mutants

Novel inhibitor of salmonella serine acetyltransferase (SAT), the enzyme that catalyzes the rate-limiting step of L-cysteine biosynthesis

Selective non-peptide vasopressin V2 receptor antagonist

Selective non-peptide vasopressin V2 receptor antagonist

Novel potent SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitor

Novel SARS-CoV-2 nsp14 Methyltransferase inhibitor

Novel SARS-CoV-2 Main Protease (Mpro) Inhibitor, inhibiting viral replication with a nanomolar EC 50 value (844 nM) in SARS-CoV-2-infected Vero E6 cells, impairing SARS-CoV-2 replication in human lung epithelial cells and human-induced pluripotent stem ce

Novel potent SARS-CoV-2 3CLpro inhibitor with IC 50 value of 73 nM