Covalent Antineoplastic Agent

Novel Potent Selective Androgen Receptor Degrader (SARD)

Novel Highly Potent Selective Androgen Receptor Degrader (SARD)

Regulator of the sarco-endoplasmic reticulum Ca -ATPase (SERCA1a), significantly slowing down the E2 to Ca2.E1 transition of SERCA1a while it affects neither phosphorylation nor dephosphorylation

Regulator of the sarco-endoplasmic reticulum Ca -ATPase (SERCA1a), significantly slowing down the E2 to Ca2.E1 transition of SERCA1a while it affects neither phosphorylation nor dephosphorylation

Broad spectrum antibiotic

Novel selective and potent dual inhibitor of thrombin and factor Xa

Novel inhibitor of TAFIa (activated thrombin-activatable fibrinolysis inhibitor)

Broad-spectrum antifungal agent, selective inhibiting the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes, in vitro and in vivo activity against F. pedrosoi

Novel Potent Non-peptidic Inhibitor of Secreted Aspartic Protease 2 (SAP2) for the Treatment of Resistant Fungal Infections

Novel potent inhibitor of Shh signaling pathway

Uridyl peptide antibiotic, exhibiting antibacterial activity against Mycobacterium tuberculosis H(37)Ra and Pseudomonas aeruginosa with MIC values of 10 and 12.5 mug/ml, respectively

Vasopeptidase or dual inhibitor of ACE and neutral endopeptidase with potential application in the treatment of hypertension and congestive heart failure

Natural antimicrobial and antitumor agent, inducing reactive oxygen species (ROS), and alterating heme biosynthesis

Opioid receptor antagonist for the treatment of alcoholism and cocaine addiction

Novel potent V-ATPase inhibitor, blocking viral entry

Antibiotic, Inhibiting CD44 expression in breast cancer cells and mammary tumor growth

ß2-adrenoceptor agonist

Natural α-glucosidase inhibitor, potently modulating Nrf 2 , NF-κB and STAT3 pathways

Natural α-glucosidase inhibitor

Novel Endogenous Reactive oxygen species (ROS)-activated HDAC inhibitor prodrug, demonstrating selective activity against multiple cancer cell lines such as HeLa, MCF-7, MDA-MB-231 and B16-F10, while remaining benign to non-cancer cells

Novel clickable HDAC inhibitor, selectively labeling HDAC complex proteins

Novel Smoothened receptor agonist

Irreversible and nonselective Monoamine_oxidase_inhibitor>monoamine oxidase inhibitor (MAOI)

Peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibiting gastrointestinal motility with no effect on experimental colitis in mice

Novel ileal Na /bile acid cotransporter inhibitor

Partial benzodiazepine inverse agonist, showing antidepressant-like pharmacological activity and acting as a cognitive enhancer

Novel Analogue of SUN-B8155, acting as a cell active and functionally-relevant agonist of calcitonin receptor (CTR), inducing different Gs or arrestin activities through CTR

Dual PPARα/γ agonist

Novel glucokinase (GK) activator