FAUC-365 analog

Novel red-light-controllable nitric oxide (NO) releaser

Novel human epidermal growth factor receptor-2 (HER2) inhibitor; Spermatocide

Neutral, nonandrogenic, progesterone-like profile progestin

Steroidal progestin

PPARalpha agonist and EC 3.5.1.23 (ceramidase) inhibitor

Neuropeptide, acting as a endogenous ligand for the nociceptin receptor (NOP, ORL-1)

Marine natural nocazine family member; Standard used in nocazine biosynthetic parthway studies

Nocazine family member

Natural Inhibitor of an Oncogenic RNA, targeting RNA folds in the nuclease processing site in the oncogenic, noncoding microRNA-18a, selectively inhibiting nuclease processing in vitro and in prostate cancer cells and triggering apoptosis

The universal precursor of the nocardicins

Moderate antibiotic agent against a broad spectrum of gram-negative bacteria

Novel non-nucleoside reverse transcriptase inhibitor (NNRTI)

Novel potent alkynyl bisubstrate inhibitor of nicotinamide N-methyltransferase (NNMT)

Iminosugar, binding to the active site of lysosomal beta-glucosidase and stabilizing the proper folding for the catalytic form, acting as a chemical chaperone that facilitate transport and maturation of acid beta-Glu

Novel selective histamine H3 antagonist

Novel inhibitor of autophagy, protecting cardiomyocytes against hypoxia/reoxygenation injury

Novel Potent and Highly Selective, Long-Acting, Peptide-Based Cholecystokinin 1 Receptor (CCK-1R) Agonist

Novel JAK2 inhibitor, displaying significant tumor growth inhibition in SET-​2 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile

Novel selective and orally bioavailable MPS1 inhibitor

Covalent and allosteric inhibitor of the ATPase VCP/p97, inducing cancer cell death

Novel Microtubule Modulator, Blocking Mitosis and Inducing Apoptosis in HeLa Cells by Binding to Tubulin

Novel Mdm2 inhibitor, acting as a negative regulator of p53, reducing viability in cell culture and suppressing tumor growth

Potent and state-dependent Nav1.7 antagonist

Novel Inhibitor of Nonsense-Mediated RNA Decay, Suppressing Nonsense p53 Mutations

Novel inhibitor of glioma-associated oncogene homologue 1 (Gli1) mediated transcription

Novel inhibitor of the Gli1 transcription, inducing apoptosis in cancer cells but not in non-cancerous cells

Novel Nm23-H1 activator, exerting cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation

Novel NLRP3 inhibitor, reducing caspase-1 activation, oligomerization of ASC, and therefore, IL-1β processing, showing a significant anti-inflammatory effect and reduced mechanical hyperalgesia at 3 and 10 mg/kg (i.p.) in an in vivo mouse of gout

Novel Enterovirus 71 Inhibitor, binding to the hydrophobic pocket in VP1 to block viral infection, exhibiting excellent antiviral activity (with an EC50 of 5.056 nM and a 100% protection rate for mice at a dose of 20 mg/kg) and low toxicity