Novel potent growth inhibitor for gammaherpesvirus-associated B-lymphomas through activation of both the NF-κB and c-Myc-mediated signaling pathways

Novel α7 nAChR agonist at human and rat receptors

Novel potent α7 nAChR partial agonist

Novel molulator of SK-IK channels [small- and intermediate-conductance Ca2(+) -activated K(+) channels]

Novel allosteric inhibitor of HCV NS3 protein function

Novel Inhibitor with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes

Potent, non-selective partial agonist at GABAA receptors with little efficacy at the alpha1 subtype and more at alpha2 and alpha3

Novel inhibitor of CDK5 translocation, increasing CDK5 accumulation in the nucleus, suppressing both cancer cell proliferation and xenograft tumorigenesis.

Novel activator of the Nrf2/HO-1 pathway, upregulating heme oxygenase-1 (HO-1) via promoting nuclear translocation of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) to regulate LPS‐induced oxidative stress in macrophages

Novel NMDA/NR2B Antagonist

Novel substrate for NAD(P)H: quinone oxidoreductase 1 (NQO1), acting as an effective intracellular ROS generator for the treatment of drug-resistant non-small-cell lung cancer

Calcilytic negative allosteric modulator of calcium-sensing receptor (CaR)

Novel potent activator of the natriuretic peptide receptor C (NPR-C) with EC 50 ~1 μM

Novel inhibitor of TGF-β1 signaling pathway, inhibiting the upregulation of MAT2A mechanistically, dose-dependently activating PP2Cα and efficiently alleviating liver fibrosis

Novel heterotrimeric G-protein Gi modulator, inhibiting GDP/GTP exchange on a Gαi subunit induced by a G-protein-coupled receptor agonist, but not on another G-protein from the Gαs family, regulating Gβγ-dependent cellular processes, most likely by causin

Novel tubulin inhibitor

Novel competitive MTH1 inhibitor

Novel tubulin inhibitor

Novel biomediator, inducing reveromycin production in Streptomyces sp. SN-593

Novel activator of 15-ADON production, significantly increasing the transcription of Tri6, a transcription factor gene necessary for trichothecene biosynthesis, in both trichothecene-inducing and noninducing culture conditions

Novel selective SIRT2 inhibitor, creating a hydrophobic cavity behind the substrate-binding pocket after a conformational change of the Zn-binding small domain of SIRT2

Novel inhibitor of Trypanosoma brucei PDEB1 (TbrPDEB1)

Novel Inhibitor of Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1)

Novel Inhibitor of Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1)

Novel stabilizer of long noncoding RNA (lncRNA) GAS5, binding to GAS5 with high affinity, and increasing GAS5 levels and glucose uptake in diabetic patient adipocytes

Second-Generation RET/VEGFR2 Inhibitor

Natural inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana

Natural inhibitor of the allosteric regulation of Hsp70

Novel potent LRRK2 inhibitor

Novel potent notum inhibitor (OPTS IC50 3.6nM; TCF-LEF EC50 220nM), showing good plasma exposure and reasonable CNS penetration