Potent P2Y6 agonist

Selective P2Y2 agonist

Selective P2Y6 agonist

Potent P2Y14 receptor agonist

Selective enhancer of the ATP effects at fast desensitizing P2X (P2X1 and P2X3) receptors

Novel selective and reproducible inhibitor of DNA synthesis in E. coli JL553

Novel potent and selective RORγT inhibitor, showing no appreciable activity against a panel of related nuclear hormone receptors

Novel potent RORγT inhibitor

Novel potent and selective RORγT inhibitor, showing no appreciable activity against a panel of related nuclear hormone receptors

Novel peripheral CB1R antagonist, being highly biased toward inhibiting CB1R-induced β-arrestin-2 (βArr2) recruitment over G-protein activation

Activator of MrgX1 receptor signaling

Novel positive allosteric modulator (PAM) of mas-related G protein-coupled receptor X1 (MRGPRX1), reducing behavioral heat hypersensitivity in humanized MRGPRX1 mice, demonstrating the therapeutic potential in treating neuropathic pain

Novel inhibitor of the main protease (Mpro) of SARS-CoV-2

Novel, potent inducer of apoptosis via the MAP kinase pathways. Inhibitor of several kinases including the tyrosine kinase FLT3-ITD

Novel highly potent and selective 5-HT2C agonist

Novel potent and selective antagonist of GluN2A-containing NMDA receptors

Novel mitochondrial permeability transition pore (mPTP) inhibitor

Novel Dual HDAC6 and Tubulin Inhibitor, Displaying Anti-tumor Ability in Human Cancer Cells

Novel tubulin polymerization inhibitor

Novel inhibitor of MPS1

Novel Mps1 Kinase Inhibitor

Novel main protease (Mpro) inhibitor, inhibiting MHV-A29, HCoV-229E, FOPV replication, and SARS-CoV-2 viral cell entry

Specific estrogen receptor α (ERα) antagonist

Potent and selective COX-2 inhibitor

Novel selective class IIb histone deacetylase inhibitor (HDACi), dose-dependently decreasing the viability of Acanthamoeba trophozoites

Novel anti-cancer agent, being more potent and safer than conventional indomethacin

Novel potent and selective microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor

Novel mixed kappa-delta opioid receptor agonist with anti-cocaine properties and reduced side-effects in rats

Potent and Specific PDE10A inhibitor

Natural antibacterial, antileishmanial, and antifungal agent