Novel highly potent orally bioavailable antiallergic agent, effectively suppressing mast cell degranulation in a dose-dependent manner (IC50, 2.54 nM for RBL-2H3 cells; 48.28 nM for peritoneal mast cells (PMCs))

Novel multitarget directed anti-Alzheimer agent, showing an IC 50 value of 0.56 ± 0.02 μM for AChE and an IC 50 value of 1.17 ± 0.09 μM for BuChE

Novel anti-AD agent, integrating Aβ-interacting and metal-binding fragments in a single molecular framework, exhibiting significant antioxidant activity and metal chelating ability, and also rescuing neuroblastoma N2A cells from Cu -induced Aβ neurotoxici

Novel Broad-Spectrum Serine β-Lactamase Inhibitor, Strongly Potentiating Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii

Novel Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

Antimitotic antibiotic with antitumor, antiprotozoal, and antifungal activities

Natural inhibitor of NADH:ubiquinone oxidoreductase

Novel Potent and Selective DYRK1 Kinase Inhibitor

Novel potent DYRK1A Kinase Inhibitor

Novel activator of nuclear factor-erythroid-related factor 2 (Nrf-2)

Novel inducer of autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg-related proteins in cisplatin-resistant CAR human oral cancer cells

Peptide hormone that causes vasoconstriction and an increase in blood pressure

Novel angiogenesis agent, showing better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells, significantly increasing the angiogenic potential of vascular endothel

Novel anticancer agent against metastatic Castration resistance and neuroendocrine variant prostate cancers (mCRPC/NEPC), exhibiting synergistic anticancer effect in combination with standard therapy docetaxel and cabazitaxel in mCRPC/NEPC, upregulating H

Novel Potent Anticonvulsant Agent with In Vitro Neuroprotection

Anticholinergic agent

Novel anti-filariasis agent, being effective in killing Brugia malayi, B. pahangi, and Litomosoides sigmodontis worms

Inhibitor of TLR2-, TLR3-, TLR4- and TLR5-mediated TNF-α, IL-1β and IL-6

Novel potent and selective leucyl-tRNA synthetase inhibitor

Novel Neuraminidase (NA) inhibitor

Novel Anti-Wolbachia Agent with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

DNA polymerase lambda and beta inhibitor

Novel inhibitor of the replication of a disease-causing polyomavirus in cell culture

Novel small molecule prodrug for use with SEAKER cells, exhibiting enhanced anticancer activity

Novel potent inhibitor of peroxiredoxin I (PrxI), increasing cellular ROS, leading to the activation of both mitochondria- and apoptosis signal-regulated kinase-1-mediated signaling pathways

Novel Metallo-β-lactamase Inhibitor

Novel agonist of AMPK signaling

Potent allosteric activator of the AMPK

Potent allosteric activator of AMPK

Novel rapid and specific inhibitor of electrophile-sensitive DEAD-box proteins with high selectivity over the wild-type enzyme