Novel dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9, inhibiting Pseudomonas aeruginosa alginate synthesis

Novel PP1-targeting Ebola Virus (EBOV) inhibitor with improved pharmacological properties

Novel Oral and Selective Prostaglandin F 2α (PGF 2α ) Receptor Antagonist

Highly potent and selective activator of isozymes CA-VA and CA-VII

Highly potent and selective activator of isozymes CA-VA and CA-VII

Novel degrader of GST-α and GST-α-EGFP fusion proteins as well as endogenous GST-π in cells and lysates

Sigma1 receptor ligand and potential atypical antipsychotic

Novel XIAP BIR2 domain-binding degrader of E3 ubiquitin ligases

Potent Activator of P53-Independent Cellular Senescence

γ-Secretase modulator (GSM) photoaffinity probe, revealing distinct allosteric binding sites on presenilin

Novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling

Novel potent Inhibitor of PI3Kalpha

Novel Selective and Potent EGFR Inhibitor, Overcoming T790M-Mediated Resistance in Non-Small Cell Lung Cancer

Antitumor antibiotic

Novel allosteric inhibitor of the tumor-promoting interaction between the oncogenic factor AIMP2-DX2 and HSP70

Novel Hsp70 agonist, showing no cellular toxicity and induced cellular stress response pathways

Novel and potent leukotriene B(4) receptor antagonist

Novel potent and highly selective inhibitor of VEGFR, exhibiting antitumor activities both in vitro and in vivo.

Potent and selective 5-HT 2A receptor antagonist

Selective 5-HT2A receptor antagonist

Anthracycline antibiotic from Streptomyces

Irreversible DNA minor groove binding alkylating agent, disrupting the nucleic acid architecture and leading to tumor cell death

Antiviral agent against influenza A, parainfluenza Sendai, coxsackie A21, and rhinovirus

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Negative control for DT2216

Novel potent and orally active activator of PP2A

Agonist of S1P receptors

Novel selective mGlu5 receptor negative allosteric modulator (NAM) with potent antidepressant and antimanic activity

Novel potent Dihydroorotate Dehydrogenase (DHODH) inhibitor

Novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor (Pfalcip cells: 0.0018 μM)