Novel Orally Active Antimalarials Targeting Plasmodium falciparum

Metabolite in the kynurenine pathway, the major route of tryptophan degradation in mammals

Major tryptophan catabolite of the kynurenine pathway, showing antiparasitic activity

Novel plant immunoregulator, being effective in delaying senescence in detached leaves while having low interactions with the cytokinin pathway, upregulating genes involved in processes associated with plant innate immunity such as cell wall remodeling an

Novel potent apoptotic inducer, inducing G2-M cell cycle arrest, blocking tubulin polymerization

Novel mammalian targeting potent inhibitor of rapamycin (mTOR) activation

Biological Active Reagents

Novel anti-Parkinson agent, targeting the D2R

Cell-permeable sialic acid analog, deacetylating intracellularly to a sialyltransferase inhibitor, abolishing SLex expression on HL-60 cells, reducing E-selectin and P-selectin binding and preventing metastasis formation in a mouse lung metastasis model

Novel inhibitor of 3C-like protease (3CLpro) of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV)

The first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor

Putative natural allosteric modulator of human Hsp90α conformational dynamics by allosteric ligand interaction at the C-terminal domain site 2

Potent endogenous estrogen

Tyrosine drivative, being a useful probe to study the role of redox active tyrosines in enzymes

Neuroprotective and proliferative agent with significantly higher stimulatory effect than that of allopregnanolone

Endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT); Potent positive allosteric modulator of the GABAA receptor

SL0101 analog, acting as a specific inhibitor of p90 ribosomal S6 kinase (RSK), being approximately 2-fold more potent at inhibiting MCF-7 cell proliferation compared to SL0101 and preferentially decreased MCF-7 cell growth, as compared to the growth of t

Natural inducer of DNA damage, cell cycle arrest, apoptosis, and autophagy in macrophages

Natural potent, selective, and efficacious inhibitor of SHP2, suppressing A549 cell proliferation (IC 50 =10.79±0.14μM), invasion and inducing cell apoptosis through SHP2/ERK1/2 and SHP2/AKT pathways

Useful pharmaceutical building block

Metabolite of thyroid hormones (thyroxine and triiodo-L-thyronine)

Inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1)

Natural inhibitor of respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane.

Inhibitor of Beta_amyloid>amyloid β-mediated cellular toxicity

Novel STING Agonist

Novel, active, and less toxic anti-tuberculosis (anti-TB) agent

Novel pro-angiogenic agent, potently promoting proliferation, migration, invasion and tube formation of human umbilical vein VECs (HUVECs) in vitro

Highly selective and relatively potent group II metabotropic glutamate receptor agonist

Novel double photocaged cathepsin B activity-based probe for monitoring the light-activation by the blue fluorescence of 7-diethylamino-4-hydroxymethyl-coumarin (DEACM) and simultaneously probe the activity of cathepsin B through the green fluorescence of

Novel inhibitor of soluble epoxide hydrolase (sEH), showing good solubility, microsomal stability, and selectivity for sEH