Nelivaptan is a non-peptide vasopressin receptor antagonist that is selective for the V1B subtype.

Baxdrostat is a aldosterone synthase inhibitor.

GB1211 is an orally available galectin-3 (Gal-3) inhibitor.

BDM2(Newly disclosed HIV-1 antiretroviral) is the first integrase-LEDGF/p75 allosteric HIV-1 inhibitor to clear Ph.

Bexotegrast is a potent inhibitor of ανβ6 integrin. Bexotegrast can be used for researching fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) (extracted from patent WO2020210404A1, compound 5).

TP0473292 is an adamantane carboxylic acid ester prodrug of TP0178894, a metabotropic glutamate 2 and 3 receptor antagonist for use as an antidepressant. TP0473292 has undergone phase 1 clinical trials for treatment of depression.

GLPG2534 is an IRAK4 inhibitor for use as a therapeutic for inflammatory skin diseases.

PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa.

Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases.

LP0200 is the prodrug of the oral allosteric IL-17A inactivator.

A2A receptor antagonist 1 is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.

CM-4620 is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM, 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively.

HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR;

NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor.

AnCoA4 (AnCoA-4, AnCoA 4) is a potent Orai1 channel inhibitor that inhibits store-operated calcium (SOC) with EC50 of 0.88 uM.

IPG7236 is a CCR8 antagonist that through the modulation of regulatory T-cells and cytotoxic T (CD8+ T) cells, displays anticancer effects. IPG7236 is currently undergoing Phase 1 clinical trials in the treatment of advanced solid tumors.

RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A.

BGB-8035 is a Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase (BTK IC50 = 1.1 nM)for B‑Cell Malignancies and Autoimmune Diseases.

BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively.

AK-2292 is a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.

CZS-241 is a Potent, Selective, and Orally Available Polo- Like Kinase 4 Inhibitor for the Treatment of Chronic Myeloid Leukemia.

M4205 is a c-KIT inhibitor, with an IC50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively.

MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia.

TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). TP0597850 has a long MMP2 dissociation half-life (t1/2=265 min).

MG624 is a potent and selective neuronal α7 nAChR antagonist with a Ki of 106 nM.

NYX-2925 is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory.

M3913 is an antitumor compound.

BAY-7081 is a Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor with very good aqueous solubility.