L-674573 is a quinoline-based compound that specifically blocks 5-lipoxygenase cellular translocation, thereby inhibiting leukotriene biosynthesis.

MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.

Varoglutamstat (PQ912) is a potent glutaminyl cyclase (QC) inhibitor with Ki values of 20-65 nM for human, rat, and mouse QC activity.

Highly selective inhibitor of the ​FK506-binding protein 51 (FKBP51)

Galicaftor (ABBV-2222/GLPG-2222) is an orally bioavailable small molecule that functions as a CFTR corrector, demonstrating potential for therapeutic development in cystic fibrosis research.

TH 287 is a first-in-class MTH1 inhibitor (IC50 value 5.0 nM) that selectively and effectively kills U2OS and other cancer cell lines, with considerably less toxicity towards several primary or immortalized cells.

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM). PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics.

RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research.

2-Mercaptobenzimidazole is the deuterated analog of 2-benzimidazolethiol, featuring four deuterium substitutions for isotopic labeling studies.

EN25 is a covalent allosteric inhibitor of glutamate-cysteine ligase (GCL), selectively targeting cysteine residue C114 on the GCLM regulatory subunit with an IC50 of 16 μM.

Naphthol AS-BI phosphate sodium salt serves as a specialized chemical substrate for enzymatic detection methods in biochemical research.

AF615 is a potent small-molecule disruptor of the CDT1/Geminin interaction, exhibiting IC50 values of 0.313 μM. This compound demonstrates selective genotoxic effects in cancer cells, including DNA synthesis inhibition, cell cycle arrest, and reduced viability. Binding studies reveal differential affinity for protein variants (Ki = 0.37 μM for Geminin-tCDT1 vs 0.75 μM for Geminin-miniCDT1).

ELOVL6-IN-5 (compound B) is a selective inhibitor targeting ELOVL6, the key regulatory enzyme for elongation of C16 fatty acids. While effectively lowering hepatic fatty acid accumulation in diet-induced obese mice, this inhibitor demonstrated limited efficacy in improving insulin sensitivity, suggesting distinct mechanisms in metabolic regulation.

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.

altering the lifespan of a eukaryotic organism; anti-viral;

inhibitor of flavivirus replication

Protein tyrosine Phosphatase 1B (PTP1B) agonist

neuroprotective effects; altering the lifespan of a eukaryotic organism;

Mycobacterium tuberculosis shikimate kinase inhibitors

useful for preventing or treating obesity, dyslipidemia, fatty liver or diabetes;

Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.