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PROTACs

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Cat. No. Product Name Field of Application Chemical Structure
DC11064 BTK PROTAC 9
BTK PROTAC 9 is a novel potent PROTAC for BTK with DC50 of 5.9 nM in cultured Ramos cells, requires simultaneous engagement of BTK and CRBN to effectively degrade BTK.
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DC11065 BTK PROTAC 10
BTK PROTAC 10 is a novel potent PROTAC for BTK with DC50 of 1.1 nM in cultured Ramos cells.
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DC10997 BRD4 degrader AT1
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
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DC11567 BETd-260 trifluoroacetate
BETd-260 trifluoroacetate (ZBC260, BETd 260 TFA) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.
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DC11569 E3 Ligand-Linker Conjugate 4
An E3 ligase ligand-linker conjugate for PROTAC...
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DC11576 E3 Ligand-Linker Conjugate 10
An E3 ligase ligand-linker conjugate for PROTAC..
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DC11563 E3 Ligand-Linker Conjugate 2
An E3 ligand- Linker Conjugate for PROTAC..
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DC11580 VHL-2
A VHL ligand for PROTAC..
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DC11581 VHL Ligand 4
A VHL ligand for PROTAC..
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DC11582 N3-PEG4-CH2COOH
A PEG4 linker for PROTAC..
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DC11577 N3-PEG3-CH2COOH
A PEG3 linker for PROTAC..
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DC11583 N3-PEG2-CH2COOH
A PEG2 linker for PROTAC..
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DC11593 Bis-PEG6-acid
A PEG linker for PROTAC..
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DC11592 Bis-PEG5-acid
A PEG linker for PROTAC..
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DC11591 Bis-PEG4-acid
A PEG linker for PROTAC..
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DC11562 Sirt2-PROTAC-1
A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM)..
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DC11867 TBK1 PROTAC 1
A novel potent, selective TBK1 PROTAC with DC50 of 12 nM, selectively degrades TBK1 with excellent selectivity against a related kinase IKKε.
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DC11564 CDK9-PROTAC
A heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.
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