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Bisindolylmaleimide IV

  Cat. No.:  DC28223   Featured
Chemical Structure
119139-23-0
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More than 5000 active chemicals with high quality for research!
Field of application
Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM). Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 119139-23-0
Chemical Name: Bisindolylmaleimide IV
Synonyms: Bisindolylmaleimide IV;2,3-Bis(1H-indol-3-yl)maleimide;3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione;BISINDOLYMALEIMIDE IV;3,4-Bis(3-indolyl)maleimide;3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione;3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione;Ro 31-6233;Arcyriarubin A;RO 31-6233;ARCYRIARUBIN A;3,4-Di(1H-indol-3-yl);BISINDOLYLMALEIMIDE IV;3,4-BIS(3-INDOLYL)MALEIMIDE;2,3-BIS(1H-INDOL-3-YL)MALEIMIDE;BisindolylMaleiMide IV [Ro 31-6233];3,4-Bis(1H-indol-3-yl)pyrrole-2,5-dione
SMILES: C1=CC=C2C(C3C(=O)NC(=O)C=3C3=CNC4=CC=CC=C34)=CNC2=C1
Formula: C20H13N3O2
M.Wt: 327.336124181747
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Bisindolylmaleimide IV (Arcyriarubin A) is a potent protein kinase C (PKC) inhibitor, with IC50s ranging from 0.1 to 0.55 μM. Bisindolylmaleimide IV also inhibits PKA (IC50=3.1-11.8μM)[1]. Bisindolylmaleimide IV is a potent, selective inhibitor of human cytomegalovirus (HCMV) replication in cell culture with an IC50 of 0.2 μM[2].
Target: PKC:0.1-0.55 μM (IC50) HCMV:0.2 μM (IC50)
In Vitro: Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO[1].
References: [1]. Davis PD, et al. Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. [2]. Slater MJ, et al. Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg Med Chem. 1999 Jun;7(6):1067-74.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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