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Atosiban

  Cat. No.:  DC23939   Featured
Chemical Structure
90779-69-4
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Field of application
Atosiban (RW22164; RWJ22164) is indeed a nonapeptide and a competitive antagonist of the vasopressin and oxytocin receptors. It is structurally similar to oxytocin but lacks the amino group at the N-terminus, making it a desamino-oxytocin analogue. Atosiban is primarily used as a tocolytic agent, which means it helps to inhibit premature labor by blocking the action of oxytocin on the uterus. This makes it particularly valuable in the management of spontaneous preterm labor, as it can help delay delivery, providing critical time for administering corticosteroids to enhance fetal lung maturity or for transferring the mother to a facility with appropriate neonatal care.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 90779-69-4
Chemical Name: Atosiban
Synonyms: Atosiban;1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin;oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l;rwj22164;ATOSIBAN ACETATE;1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin;[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2;(2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin;(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin;1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin;RW22164;Tractocile;(2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S;Antocin;Rwj 22164;dTVT;081D12SI0Z;Atosibanum [INN-Latin];deTVT;Atosibanum;ORF 22164;Antocin II;Atosiban [USAN:INN:BAN];1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-threonine-8-L-ornithineoxytocin;C43H67N11O12S2;1-(3-Mercaptopropanoic acid)-2-(O-ethy;1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane, cyclic peptide deriv. (ZCI);Oxytocin, 1-(3-mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine- (ZCI);Antocile;CAP 449;CAP 476;CAP 581;F 314;RW 22164;DTXSID90861122;CAS_90779-69-4;(2S)-N-[5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,16R)-7-(2-amino-2-oxoethyl)-13-[(2S)-butan-2-yl]-16-[(4-ethoxyphenyl)methyl]-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;AKOS015895131;MFCD00672436;NCGC00387803-01;BCP02053;1-[7-(2-Amino-2-oxoethyl)-13-(butan-2-yl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl]prolylornithylglycinamide;SY301205;BDBM86209;90779-69-4;CAP-476;CAP-476;CAP-476;CAP-476;CAP-476;ATOSIBAN (MART.);ATOSIBAN (MART.);ATOSIBAN (MART.);ATOSIBAN (MART.);ATOSIBAN (MART.);d(D-Tyr(Et)2,Thr4,Orn8)vasotocin;d(D-Tyr(Et)2,Thr4,Orn8)vasotocin;d(D-Tyr(Et)2,Thr4,Orn8)vasotocin;d(D-Tyr(Et)2,Thr4,Orn8)vasotocin;d(D-Tyr(Et)2,Thr4,Orn8)vasotocin;RW22164;RWJ22164;RW22164;RWJ22164;RW22164;RWJ22164;RW22164;RWJ22164;RW22164;RWJ22164;C77085;C77085;C77085;C77085;C77085;CAS-90779-69-4;CAS-90779-69-4;CAS-90779-69-4;CAS-90779-69-4;CAS-90779-69-4;Atosibanum (INN-Latin);Atosibanum (INN-Latin);Atosibanum (INN-Latin);Atosibanum (INN-Latin);Atosibanum (INN-Latin);(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt;(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt;(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt;(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt;(Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt;DTXSID8048991;DTXSID8048991;DTXSID8048991;DTXSID8048991;DTXSID8048991;GTPL2213;...
SMILES: C([C@@H]1CSSCCC(=O)N[C@H](CC2C=CC(OCC)=CC=2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC(=O)N)C(=O)N1)(N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)NCC(=O)N)=O
Formula: C43H67N11O12S2
M.Wt: 994.188587427139
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Atosiban(RW22164; Tractocile) is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra). Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane.As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.[1][2] In human pre-term labour, atosiban, at the recommended dosage, antagonises uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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