XMD17-109|cas 1435488-37-1|From Supplier DC Chemicals

Cas No.:	1435488-37-1
Chemical Name:	XMD17 109,XMD17109
Synonyms:	XMD17 109,XMD17109
SMILES:	N(C)1C(=O)C2=CC=CC=C2N(C2CCCC2)C2=NC(NC3=CC=C(C(N4CCC(N5CCN(C)CC5)CC4)=O)C=C3OCC)=NC=C12
Formula:	C₃₆H₄₆N₈O₃
M.Wt:	638.8
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

XMD17-109 is a novel, specific ERK-5 inhibitor, with an IC50 of 162 nM.

In Vitro:

XMD17-109 (Compound 26) inhibits ERK5 biochemically with an IC50 of 0.162 ± 0.006 μM, and blocks pidermal growth factor induced ERK5 autophosphorylation with an EC50 of 0.09 ± 0.03 μM in cells. XMD17-109 also inhibits LRRK2[G2019S] with an IC50 of 339 nM[1]. XMD17-109 demonstrats low nanomolar cellular activity judged by the significant dose-dependent reduction of mobility shifted phosphorylated ERK5 bands from sorbitol stimulated cells. XMD17-109 completely inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM and has an EC50 of 4.2 μM[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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