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Branaplam hydrochloride

  Cat. No.:  DC71300   Featured
Chemical Structure
1562338-39-9
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More than 5000 active chemicals with high quality for research!
Field of application
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1562338-39-9
Chemical Name: LMI070 HCl
Synonyms: LMI070 HCl
SMILES: OC1C=C(C2=CNN=C2)C=CC=1C1N=NC(OC2CC(C)(C)NC(C)(C)C2)=CC=1.Cl
Formula: C22H28ClN5O2
M.Wt: 429.94
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC71300 Branaplam hydrochloride Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
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