DPPE-PEG is a synthetic lipid used in liposomes with unique properties and a wide range of applications. Firstly, DPPE-PEG exhibits excellent biocompatibility and solubility, allowing it to remain stable within the biological system and be efficiently absorbed and metabolized. Additionally, DPPE-PEG possesses good surface activity, which helps stabilize the liposome structure and enhance its stability.

DPPE-PEG is a synthetic lipid used in liposomes with unique properties and a wide range of applications. Firstly, DPPE-PEG exhibits excellent biocompatibility and solubility, allowing it to remain stable within the biological system and be efficiently absorbed and metabolized. Additionally, DPPE-PEG possesses good surface activity, which helps stabilize the liposome structure and enhance its stability.

DPPE-PEG is a synthetic lipid used in liposomes with unique properties and a wide range of applications. Firstly, DPPE-PEG exhibits excellent biocompatibility and solubility, allowing it to remain stable within the biological system and be efficiently absorbed and metabolized. Additionally, DPPE-PEG possesses good surface activity, which helps stabilize the liposome structure and enhance its stability.

5-HT3 antagonist 4 is a 5-HT3 receptor (5HT3R) antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice.

DPPE-PEG is a synthetic lipid used in liposomes with unique properties and a wide range of applications. Firstly, DPPE-PEG exhibits excellent biocompatibility and solubility, allowing it to remain stable within the biological system and be efficiently absorbed and metabolized. Additionally, DPPE-PEG possesses good surface activity, which helps stabilize the liposome structure and enhance its stability.

BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.

DVR-01 is a HBV inhibitor with EC50 values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively. DVR-01 shows antiviral activity against drug-resistant HBV mutants with EC50s of 2.403-3.273 μM. DVR-01 can be used for the research of HBV infection and related diseases.

JNJ10191584 (VUF6002) is an orally active and selective histamine H4 receptor antagonist with a Ki value of 26 nM. JNJ10191584 shows 540-fold selectivity to H4 receptor over H3 receptor with a Ki value of 14.1 μM. JNJ10191584 inhibits chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively.

SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

UNC1021 is a selective L3MBTL3 inhibitor with an IC50 of 0.048 μM.

Oct4 inducer-1 (compound OAC-3) is a potent Oct4 activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time.

Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively; shows no activity against Class IIa HDAC4/4/7/9 and HDAC6; demonstrates significant and broad spectrum in vitro and in vivo antitumor activity, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.

Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

RGT1383 is a novel GLP-1R agonist, an analog of PF-06882961.

SW203668 is a potent, tumor-specific inhibitor of stearoyl CoA desaturase (SCD) with better bioavailability than SW208108.

AG-120 is a first-in-class, orally available, selective, potent inhibitor of the mutated IDH1 protein.

Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively.

FLT3/AXL inhibitor

Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor INC280 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. Capmatinib was approved in 2020.

Tepotinib (EMD1214063, MSC2156119) is a potent, specific and ATP-competitive inhibitor of MET (HGFR) with IC50 of 23 nM for MET WT autophosphorylation and 2.2-42.6 nM for M1268T, Y1248H, H1112Y, L1213V, H1112L, V1110I, V1206L, and V1238I MET-mutated varia

ABBV-CLS-484 (AC-484) is a novel PTPN2/N1 inhibitor with IC50 of 2.2 nM. AC-484 improves oral bioavailability across different species.

DSF-102 (DSF102) is a small molecule EGFR inhibitor that interacts with the extracellular domain (ECD) of EGFR, inhibits the interaction with the EGF instead of blocking the intracellular kinase activity, shows inhibition of EGFR dimerization with IC50 of

Sotorasib racemate (Compound A) is an orally active racemate of Sotorasib, a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.

AMG-510 is a specific covalent inhibitor of K-RAS(G12C) with potential antineoplastic activity.

HRO761 is a potent, selective, allosteric WRN inhibitor with IC50 of 100 nM (ATPase assay) and GI50 of 40 nM (SW48 cells), respectively. HRO761 binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation.

3β-[N-(N′,N′-Dimethylaminoethyl)carbamoyl]cholesterol, a lipid, has been investigated in cancer gene therapy and vaccine delivery system.

VVD-133214 is a covalent allosteric inhibitor of WRN helicase with potent cellular TE50 in both human and mouse WRN helicase DNA unwinding assays. VVD-133214 potently inhibits cell growth in MSI-H HCT-116 cells with GI50 of  0.066 μM but in neither MSS SW480 nor HCT-116 WRN C727A mutant cells.

ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.